Vello Tougu
Overview
Explore the profile of Vello Tougu including associated specialties, affiliations and a list of published articles.
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Snapshot
Articles
27
Citations
454
Followers
0
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Recent Articles
1.
Kirss S, Reinapu A, Kabin E, Smirnova J, Tougu V, Palumaa P
Front Mol Biosci
. 2024 Sep;
11:1451536.
PMID: 39290994
Alzheimer's disease (AD) is characterized by classic hallmarks such as amyloid plaques and neurofibrillary tangles, however, intensive research has broadened its scope to explore additional underlying mechanisms. Notably, disruptions in...
2.
Noormagi A, Golubeva T, Berntsson E, Warmlander S, Tougu V, Palumaa P
ACS Omega
. 2023 Sep;
8(37):33912-33919.
PMID: 37744839
Copper is an indispensable biometal, primarily serving as a redox-competent cofactor in numerous proteins. Apart from preformed copper-binding sites within the protein structures, small peptide motifs exist called ATCUN, which...
3.
Berntsson E, Vosough F, Noormagi A, Padari K, Asplund F, Gielnik M, et al.
ACS Chem Neurosci
. 2023 Jul;
14(15):2618-2633.
PMID: 37487115
Uranium (U) is naturally present in ambient air, water, and soil, and depleted uranium (DU) is released into the environment via industrial and military activities. While the radiological damage from...
4.
Berntsson E, Sardis M, Noormagi A, Jarvet J, Roos P, Tougu V, et al.
ACS Omega
. 2022 Aug;
7(33):28924-28931.
PMID: 36033665
Mercury intoxication typically produces more severe outcomes in people with the ε gene, which codes for the ApoE4 variant of apolipoprotein E, compared to individuals with the ε and ε...
5.
Smirnova J, Gavrilova J, Noormagi A, Valmsen K, Pupart H, Luo J, et al.
Molecules
. 2022 May;
27(10).
PMID: 35630637
The tight binding of Cu and Zn ions to superoxide dismutase 1 (SOD1) maintains the protein stability, associated with amyotrophic lateral sclerosis (ALS). Yet, the quantitative studies remain to be...
6.
Metsla K, Kirss S, Laks K, Sildnik G, Palgi M, Palumaa T, et al.
J Alzheimers Dis
. 2021 Dec;
85(2):715-728.
PMID: 34864665
Background: Alzheimer's disease (AD) is an age-dependent progressive neurodegenerative disorder and the most common cause of dementia. The treatment and prevention of AD present immense yet unmet needs. One of...
7.
Friedemann M, Tougu V, Palumaa P
FEBS Open Bio
. 2020 Apr;
10(6):1072-1081.
PMID: 32255544
Diethyl pyrocarbonate (DEPC) has been primarily used as a residue-specific modifying agent to study the role of His residues in peptide/protein and enzyme function; however, its action is not specific,...
8.
Kubo A, Vasiliev G, Vija H, Krishtal J, Tougu V, Visnapuu M, et al.
Arch Toxicol
. 2020 Apr;
94(5):1561-1573.
PMID: 32253467
Clinical use of CuO nanoparticles (NPs) as antibacterials can be hampered by their toxicity to human cells. We hypothesized that certain surface functionalizations of CuO NPs may render NPs toxic...
9.
Kirsipuu T, Zadoroznaja A, Smirnova J, Friedemann M, Plitz T, Tougu V, et al.
Sci Rep
. 2020 Apr;
10(1):5686.
PMID: 32231266
It has been reported that Cu(II) ions in human blood are bound mainly to serum albumin (HSA), ceruloplasmin (CP), alpha-2-macroglobulin (α2M) and His, however, data for α2M are very limited...
10.
Krishtal J, Metsla K, Bragina O, Tougu V, Palumaa P
J Alzheimers Dis
. 2019 Aug;
71(3):879-887.
PMID: 31450506
Alzheimer's disease (AD) is a currently incurable neurodegenerative disorder being the major form of dementia worldwide. AD pathology is initiated by cerebral aggregation of amyloid-β (Aβ) peptides in the form...