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Vani P Mocharla

Explore the profile of Vani P Mocharla including associated specialties, affiliations and a list of published articles. Areas
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Articles 11
Citations 607
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Recent Articles
1.
Maguire C, Chen Z, Mocharla V, Sriram M, Strecker T, Hamel E, et al.
Medchemcomm . 2018 Nov; 9(10):1649-1662. PMID: 30429970
The natural products colchicine and combretastatin A-4 () have provided inspiration for the discovery and development of a wide array of derivatives and analogues that inhibit tubulin polymerization through a...
2.
Hugenberg V, Hermann S, Galla F, Schafers M, Wunsch B, Kolb H, et al.
Nucl Med Biol . 2016 May; 43(7):424-37. PMID: 27179748
Introduction: Dysregulated MMP expression or activation is associated with several diseases. To study MMP activity in vivo by means of PET a radiolabeled MMP inhibitor (MMPI) functioning as radiotracer has...
3.
Doss M, Kolb H, Walsh J, Mocharla V, Zhu Z, Haka M, et al.
Mol Imaging Biol . 2014 Apr; 16(5):739-46. PMID: 24696183
Purpose: [(18) F]VM4-037 has been developed as a positron emission tomography (PET) imaging marker to detect carbonic anhydrase IX (CA-IX) overexpression and is being investigated for use as a surrogate...
4.
Xia C, Chen G, Gangadharmath U, Gomez L, Liang Q, Mu F, et al.
Mol Imaging Biol . 2013 May; 15(6):748-57. PMID: 23689985
Purpose: A novel caspase-3 substrate-based probe [(18)F]-CP18 was evaluated as an in vivo positron emission tomography (PET) imaging agent for monitoring apoptosis in tumors. Methods: Uptake of [(18)F]-CP18 in cell...
5.
Su H, Chen G, Gangadharmath U, Gomez L, Liang Q, Mu F, et al.
Mol Imaging Biol . 2013 May; 15(6):739-47. PMID: 23681757
Purpose: We identified and validated [(18)F]-CP18, a DEVD (the caspase 3 substrate recognition motif) containing substrate-based compound as an imaging tracer for caspase-3 activity in apoptotic cells. Procedures: CP18 was...
6.
Xia C, Arteaga J, Chen G, Gangadharmath U, Gomez L, Kasi D, et al.
Alzheimers Dement . 2013 Feb; 9(6):666-76. PMID: 23411393
Objective: We wished to develop a highly selective positron emission tomography (PET) imaging agent targeting PHF-tau in human Alzheimer's disease (AD) brains. Methods: To screen potential tau binders, human AD...
7.
Mocharla V, Walsh J, Padgett H, Su H, Fueger B, Weber W, et al.
ChemMedChem . 2012 Dec; 8(1):43-8. PMID: 23208787
CA II makes a good PET: Discovering positron emission tomography (PET) probes with high target affinities is challenging. PET probe discovery using in situ click chemistry uses (19) F-bearing fragments...
8.
Zhang W, Arteaga J, Cashion D, Chen G, Gangadharmath U, Gomez L, et al.
J Alzheimers Dis . 2012 Jun; 31(3):601-12. PMID: 22683529
Senile plaques and neurofibrillary tangles are prominent neuropathological hallmarks in Alzheimer's disease and are considered to be targets for therapeutic intervention as well as biomarkers for diagnostic in vivo imaging...
9.
Doss M, Kolb H, Zhang J, Belanger M, Stubbs J, Stabin M, et al.
J Nucl Med . 2012 Apr; 53(5):787-95. PMID: 22499613
Unlabelled: 2-((2S,5R,8S,11S)-5-benzyl-8-(4-((2S,3R,4R,5R,6S)-6-((2-(4-(3-(18)F-fluoropropyl)-1H-1,2,3-triazol-1-yl)acetamido)methyl)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxamido)butyl)-11-(3-guanidinopropyl)-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentaazacyclopentadecan-2-yl)acetic acid ((18)F-RGD-K5) has been developed as an α(v)β(3) integrin marker for PET. The purpose of this study was to determine the biodistribution and estimate the radiation dose from...
10.
Wang J, Sui G, Mocharla V, Lin R, Phelps M, Kolb H, et al.
Angew Chem Int Ed Engl . 2006 Aug; 45(32):5276-81. PMID: 16927322
No abstract available.