Vanessa G P Severino
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Explore the profile of Vanessa G P Severino including associated specialties, affiliations and a list of published articles.
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8
Citations
19
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Recent Articles
1.
Sousa L, Oliveira A, Arantes A, Junqueira J, Alexandre G, Severino V, et al.
Molecules
. 2023 May;
28(9).
PMID: 37175219
Glioblastoma (GBM) is an incurable primary brain tumor with a poor prognosis. Resection, radiation therapy, and temozolomide (TMZ) are insufficient to increase survival, making the treatment limited. Thus, the search...
2.
de Faria R, Oliveira P, de Carvalho M, Peixoto B, Severino V, Tinoco L, et al.
J Pharm Biomed Anal
. 2022 Feb;
211:114614.
PMID: 35123329
In Leishmania donovani, the causative protozoan of visceral leishmaniasis, nucleoside hydrolase enzyme (NH) is fundamental for the biosynthesis of its DNA and RNA. Therefore, LdNH is considered a potential target...
3.
Gomes I, Silva-Oliveira R, Oliveira Silva V, Rosa M, Vital P, Barbosa M, et al.
Molecules
. 2019 Nov;
24(21).
PMID: 31683835
Plant-based compounds are an option to explore and perhaps overcome the limitations of current antitumor treatments. Mart. is a plant with a broad spectrum of biological activities, but its antitumor...
4.
Monteiro A, Seidl C, Severino V, Cardoso C, Castro-Gamboa I
R Soc Open Sci
. 2018 Jan;
4(11):170854.
PMID: 29291077
Biotransformation of natural products by filamentous fungi is a powerful and effective approach to achieve derivatives with valuable new chemical and biological properties. Although diterpenoid substrates usually exhibit good susceptibility...
5.
Monteiro A, Batista Jr J, Machado M, Severino R, Blanch E, Bolzani V, et al.
J Nat Prod
. 2015 Jun;
78(6):1451-5.
PMID: 26039872
Chemical investigations of the ethanolic extracts from the flowers and leaves of Hymenaea stigonocarpa Mart. ex Hayne afforded one new ent-halimane diterpenoid, 18-hydroxy-ent-halima-1(10),13-(E)-dien-15-oic acid (1), together with five known compounds...
6.
Nebo L, Varela R, Molinillo J, Severino V, Sarria A, Cazal C, et al.
Nat Prod Commun
. 2015 Apr;
10(1):17-20.
PMID: 25920211
Limonoids and triterpenes are the largest groups of secondary metabolites and have notable biological activities. Meliaceae and Rutaceae are known for their high diversity of metabolites, including limonoids, and are...
7.
Severino V, de Freitas S, Braga P, Forim M, da Silva M, Fernandes J, et al.
Molecules
. 2014 Aug;
19(8):12031-47.
PMID: 25120055
Previous investigations of H. oreadica reported the presence of a wide spectrum of complex limonoids and dihydrocinnamic acids. Our interest in the Rutaceae motivated a reinvestigation of H. oreadica, H....
8.
Severino V, Braga P, da Silva M, Fernandes J, Vieira P, Theodoro J, et al.
Phytochemistry
. 2012 Feb;
76:52-9.
PMID: 22289621
The dichloromethane extract from taproots of Hortia oreadica afforded six limonoids, these are 9,11-dehydro-12α-acetoxyhortiolide A, hortiolide C, 11α-acetoxy-15-deoxy-6-hydroxyhortiolide C, hortiolide D, hortiolide E, 12β-hydroxyhortiolide E, in addition to the known...