Valerio Farfariello
Overview
Explore the profile of Valerio Farfariello including associated specialties, affiliations and a list of published articles.
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Articles
34
Citations
702
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Recent Articles
1.
Nehme J, Mesilmany L, Varela-Eirin M, Brandenburg S, Altulea A, Lin Y, et al.
Nat Aging
. 2024 May;
4(6):771-782.
PMID: 38724734
Excessive amounts of reactive oxygen species (ROS) lead to macromolecular damage and high levels of cell death with consequent pathological sequelae. We hypothesized that switching cell death to a tissue...
2.
Loeck T, Rugi M, Todesca L, Kalinowska P, Soret B, Neumann I, et al.
Pflugers Arch
. 2023 Nov;
476(1):147.
PMID: 37922097
No abstract available.
3.
Loeck T, Rugi M, Todesca L, Kalinowska P, Soret B, Neumann I, et al.
Pflugers Arch
. 2023 Aug;
475(10):1225-1240.
PMID: 37566113
Pancreatic stellate cells (PSCs) that can co-metastasize with cancer cells shape the tumor microenvironment (TME) in pancreatic ductal adenocarcinoma (PDAC) by producing an excessive amount of extracellular matrix. This leads...
4.
Audero M, Carvalho T, Ruffinatti F, Loeck T, Yassine M, Chinigo G, et al.
Cancers (Basel)
. 2023 May;
15(9).
PMID: 37174038
Pancreatic Ductal Adenocarcinoma (PDAC) is characterized by an acidic microenvironment, which contributes to therapeutic failure. So far there is a lack of knowledge with respect to the role of the...
5.
Lewuillon C, Guillemette A, Titah S, Shaik F, Jouy N, Labiad O, et al.
Int J Mol Sci
. 2022 May;
23(10).
PMID: 35628366
Acute myeloid leukemia (AML) is a hematological malignancy with a high risk of relapse. This issue is associated with the development of mechanisms leading to drug resistance that are not...
6.
Farfariello V, Gordienko D, Mesilmany L, Touil Y, Germain E, Fliniaux I, et al.
Nat Commun
. 2022 Feb;
13(1):956.
PMID: 35177596
Cellular senescence is implicated in a great number of diseases including cancer. Although alterations in mitochondrial metabolism were reported as senescence drivers, the underlying mechanisms remain elusive. We report the...
7.
Dubois C, Kondratska K, Kondratskyi A, Morabito A, Mesilmany L, Farfariello V, et al.
Biochim Biophys Acta Mol Cell Res
. 2021 Apr;
1868(7):119023.
PMID: 33798603
Changes in cytosolic free Ca concentration play a central role in many fundamental cellular processes including muscle contraction, neurotransmission, cell proliferation, differentiation, gene transcription and cell death. Many of these...
8.
Ziegler D, Vindrieux D, Goehrig D, Jaber S, Collin G, Griveau A, et al.
Nat Commun
. 2021 Feb;
12(1):720.
PMID: 33526781
Cellular senescence is induced by stresses and results in a stable proliferation arrest accompanied by a pro-inflammatory secretome. Senescent cells accumulate during aging, promoting various age-related pathologies and limiting lifespan....
9.
Farfariello V, Prevarskaya N, Gkika D
Rev Physiol Biochem Pharmacol
. 2020 Aug;
181:39-56.
PMID: 32737754
In the last three decades, a growing number of studies have implicated ion channels in all essential processes of prostate carcinogenesis, including cell proliferation, apoptosis, migration, and angiogenesis. The changes...
10.
Dubois C, Kondratskyi A, Bidaux G, Noyer L, Vancauwenberghe E, Farfariello V, et al.
iScience
. 2020 Jun;
23(7):101263.
PMID: 32585596
Mitochondria are important cell death checkpoints, and mitochondrial Ca overload is considered as a potent apoptotic intrinsic pathway inducer. Here, we report that this Ca apoptosis link is largely ineffective...