Valerie Le Sage
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Explore the profile of Valerie Le Sage including associated specialties, affiliations and a list of published articles.
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45
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944
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Recent Articles
1.
Robinson-McCarthy L, Zirckel K, Simmons H, Le Sage V, McCarthy K
bioRxiv
. 2025 Mar;
PMID: 40060653
A panzootic of highly pathogenic avian influenza (HPAI) H5N1 viruses from clade 2.3.4.4b has triggered a multistate outbreak in United States dairy cattle and an unknown number of human infections....
2.
Le Sage V, Werner B, Merrbach G, Petnuch S, OConnell A, Simmons H, et al.
Emerg Infect Dis
. 2025 Mar;
31(3):477-487.
PMID: 40023796
The emergence of highly pathogenic avian influenza A(H5N1) virus in dairy cattle herds across the United States in 2024 caused several human infections. Understanding the risk for spillover infections into...
3.
Lederhofer J, Borst A, Nguyen L, Gillespie R, Williams C, Walker E, et al.
bioRxiv
. 2024 Dec;
PMID: 39677750
Influenza has been responsible for multiple global pandemics and seasonal epidemics and claimed millions of lives. The imminent threat of a panzootic outbreak of avian influenza H5N1 virus underscores the...
4.
Shetty N, Shephard M, Rockey N, Macenczak H, Traenkner J, Danzy S, et al.
J Virol
. 2024 Nov;
98(12):e0161224.
PMID: 39589151
Importance: We use a controlled human infection model to assess respiratory and aerosol shedding kinetics to expand our knowledge of influenza infection dynamics and help inform future studies aimed at...
5.
Le Sage V, Werner B, Merrbach G, Petnuch S, OConnell A, Simmons H, et al.
bioRxiv
. 2024 Nov;
PMID: 39484442
The emergence of highly pathogenic H5N1 avian influenza in dairy cattle herds across the United States has caused multiple mild human infections. There is an urgent need to understand the...
6.
Rockey N, Le Sage V, Shephard M, Vargas-Maldonado N, Vu M, Brown C, et al.
Proc Natl Acad Sci U S A
. 2024 Oct;
121(33):e2322660121.
PMID: 39361828
Sustained community spread of influenza viruses relies on efficient person-to-person transmission. Current experimental transmission systems do not mimic environmental conditions (e.g., air exchange rates, flow patterns), host behaviors, or exposure...
7.
Finnen R, Muradov J, Le Sage V, Banfield B
J Virol
. 2024 Aug;
98(9):e0065624.
PMID: 39136460
Importance: It is well known that post-translational modification of proteins by phosphorylation can regulate protein function. Here, we determined that phosphorylation of the multifunctional HSV-2 tegument protein pUL21 requires the...
8.
Le Sage V, Campbell A, Reed D, Duprex W, Lakdawala S
Emerg Infect Dis
. 2024 Jun;
30(8):1721-1723.
PMID: 38914418
Examining the persistence of highly pathogenic avian influenza A(H5N1) from cattle and human influenza A(H1N1)pdm09 pandemic viruses in unpasteurized milk revealed that both remain infectious on milking equipment materials for...
9.
Le Sage V, Rockey N, French A, McBride R, McCarthy K, Rigatti L, et al.
Nat Commun
. 2024 Jun;
15(1):5025.
PMID: 38871701
Influenza A viruses in swine have considerable genetic diversity and continue to pose a pandemic threat to humans due to a potential lack of population level immunity. Here we describe...
10.
Le Sage V, Campbell A, Reed D, Duprex W, Lakdawala S
medRxiv
. 2024 Jun;
PMID: 38826283
Spillover of highly pathogenic avian H5N1 into the cattle population poses a risk to humans through the close contact with farm workers. High viral loads of influenza viruses in the...