Valerie Booth
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Explore the profile of Valerie Booth including associated specialties, affiliations and a list of published articles.
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42
Citations
342
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Recent Articles
1.
Heravi S, Power J, Yethiraj A, Booth V
Protein Sci
. 2024 Feb;
33(3):e4894.
PMID: 38358134
α-synuclein is an intrinsically disordered protein (IDP) whose aggregation in presynaptic neuronal cells is a pathological hallmark of Lewy body formation and Parkinson's disease. This aggregation process is likely affected...
2.
Kumari S, Morrow M, Booth V
BBA Adv
. 2023 Apr;
2:100057.
PMID: 37082590
Understanding how non-lipid components of bacteria affect antimicrobial peptide (AMP)-induced membrane disruption is important for a comprehensive understanding of AMP mechanisms and informing AMP-based drug development. This study investigates how...
3.
Kumari S, Morrow M, Booth V
Biochim Biophys Acta Biomembr
. 2022 Sep;
:184053.
PMID: 36155053
Understanding how non-lipid components of bacteria affect antimicrobial peptide (AMP)-induced membrane disruption is important for a comprehensive understanding of AMP mechanisms and informing AMP-based drug development. This study investigates how...
4.
Montero Vega S, Booth V, Rowley C
J Phys Chem B
. 2022 Jul;
126(29):5473-5480.
PMID: 35829704
Antimicrobial peptides (AMPs) offer advantages over conventional antibiotics; for example, bacteria develop more resistance to small-molecule antibiotics than to AMPs. The interaction of the AMPs with the lipopolysaccharide (LPS) layer...
5.
Kumari S, Booth V
Int J Mol Sci
. 2022 Mar;
23(5).
PMID: 35269882
Much of the work probing antimicrobial peptide (AMP) mechanisms has focussed on how these molecules permeabilize lipid bilayers. However, AMPs must also traverse a variety of non-lipid cell envelope components...
6.
Wijesinghe A, Kumari S, Booth V
PLoS One
. 2022 Mar;
17(3):e0255753.
PMID: 35259149
While peptides can be excellent therapeutics for several conditions, their limited in vivo half-lives have been a major bottleneck in the development of therapeutic peptides. Conjugating the peptide to an...
7.
Booth V
Front Med Technol
. 2022 Jan;
2:621572.
PMID: 35047897
Solid state NMR has been tremendously useful in characterizing the structure and dynamics of model membranes composed of simple lipid mixtures. Model lipid studies employing solid state NMR have included...
8.
Abdelfatah N, Mostafa A, French C, Doucette L, Penney C, Lucas M, et al.
Hum Genet
. 2021 Oct;
141(3-4):965-979.
PMID: 34633540
Otosclerosis is a bone disorder of the otic capsule and common form of late-onset hearing impairment. Considered a complex disease, little is known about its pathogenesis. Over the past 20 ...
9.
Sandhu G, Morrow M, Booth V
Biochim Biophys Acta Biomembr
. 2020 Aug;
1862(11):183444.
PMID: 32822647
Gad-1 and Gad-2 are helical, histidine-rich antimicrobial peptides (AMPs) from paralogous genes in cod. N and H solid state nuclear magnetic resonance (NMR) were used to characterize their lipid-bound structures...
10.
Sandhu G, Booth V, Morrow M
Langmuir
. 2020 Aug;
36(33):9867-9877.
PMID: 32787066
The histidine-rich antimicrobial peptides Gad-1 and Gad-2, from paralogous genes in cod, provide an opportunity to examine the effect of charge and nonelectrostatic factors on peptide-vesicle interaction and on peptide...