Valentina Shakhnovich
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Explore the profile of Valentina Shakhnovich including associated specialties, affiliations and a list of published articles.
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47
Citations
321
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Recent Articles
1.
Kumar A, Tatarian J, Shakhnovich V, Chevalier R, Sudman M, Lovell D, et al.
Metabolites
. 2024 Sep;
14(9).
PMID: 39330506
Identification of disease and therapeutic biomarkers remains a significant challenge in the early diagnosis and effective treatment of juvenile idiopathic arthritis (JIA). In this study, plasma metabolomic profiling was conducted...
2.
Keever-Keigher M, Harvey L, Williams V, Vyhlidal C, Ahmed A, Johnston J, et al.
Front Immunol
. 2024 Aug;
15:1420208.
PMID: 39192974
Introduction: Chronic inflammation of the gastrointestinal tissues underlies gastrointestinal inflammatory disorders, leading to tissue damage and a constellation of painful and debilitating symptoms. These disorders include inflammatory bowel diseases (Crohn's...
3.
Dunlap T, Gonzalez D, Kyler K, Helfer V, Williams V, Friesen C, et al.
J Clin Pharmacol
. 2024 Aug;
PMID: 39189986
Pediatric obesity is a growing health concern, affecting millions of children worldwide. While pharmacokinetic (PK) changes in numerous commonly prescribed medications have been linked to obesity, the physiological mechanisms driving...
4.
Dalal S, Ajit D, Friesen C, Shakhnovich V, Singh M, Colombo J, et al.
J Pediatr Gastroenterol Nutr
. 2024 Aug;
79(5):991-999.
PMID: 39149805
Objective: In functional dyspepsia patients, duodenal mucosal eosinophilia has been associated with early satiety but is not present in all patients suggesting varied pathways to symptom generation. The objective of...
5.
Posson P, Hibbing P, Damiot A, Carbuhn A, White D, Shakhnovich V, et al.
Child Obes
. 2024 Jul;
21(1):30-38.
PMID: 39052506
The objectives of the study were (1) to assess whether resting energy expenditure (REE) equations have comparable validity for adolescents with overweight/obesity vs. adolescents with healthy weight and (2) to...
6.
Di Lorenzo C, Robert J, Rodriguez-Araujo G, Shakhnovich V, Xie W, Nurko S, et al.
J Pediatr Gastroenterol Nutr
. 2024 Jul;
79(3):510-518.
PMID: 38962910
Objectives: Linaclotide, a guanylate cyclase-C agonist, was recently approved in the United States for the treatment of children 6-17 years of age with functional constipation (FC). This study evaluated the...
7.
Thompson E, Jeong A, Helfer V, Shakhnovich V, Edginton A, Balevic S, et al.
CPT Pharmacometrics Syst Pharmacol
. 2024 Jun;
13(8):1394-1408.
PMID: 38837864
Pantoprazole is a proton pump inhibitor indicated for the treatment of gastroesophageal reflux disease, a condition that disproportionately affects children with obesity. Appropriately dosing pantoprazole in children with obesity requires...
8.
Friesen C, Shakhnovich V, Toren P, Retke B, Schurman J, Colombo J, et al.
Paediatr Drugs
. 2024 May;
26(4):451-457.
PMID: 38771467
Background And Objective: Mast cells have been implicated in abdominal pain-associated disorders of gut-brain interaction, such as functional dyspepsia. As such, ketotifen, a second-generation antihistamine and mast cell stabilizer, could...
9.
Kremer S, Shakhnovich V, Riffel A, Harvey L, Borges C
Biopreserv Biobank
. 2024 Apr;
22(6):578-585.
PMID: 38651617
Blood plasma storage is a crucial element of pediatric biobanking. Improperly stored or handled specimens (e.g., at > -30°C) can result in altered biomolecular compositions that no longer reflects reality....
10.
Kyler K, Gaedigk A, Abdel-Rahman S, Staggs V, Pearce R, Toren P, et al.
Clin Transl Sci
. 2024 Apr;
17(4):e13782.
PMID: 38629502
In this brief report, we provide an analysis of the influence of a novel CYP2C haplotype (CYP2C:TG) on proton pump inhibitor (PPI) pharmacokinetics (PK) in children. The CYP2C:TG haplotype has...