Valentin Kohler
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Explore the profile of Valentin Kohler including associated specialties, affiliations and a list of published articles.
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24
Citations
373
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Recent Articles
1.
Hua Y, Zou Z, Prescimone A, Ward T, Mayor M, Kohler V
Chem Sci
. 2024 Jul;
15(28):10997-11004.
PMID: 39027294
The addition of a sulfhydryl group to water-soluble -alkyl(-nitrostyryl)pyridinium ions (NSPs) followed by fast and irreversible cyclization and aromatization results in a stable S-C sp-bond. The reaction sequence, termed Click...
2.
Strauss M, Shayeghi A, Mauser M, Geyer P, Kostersitz T, Salapa J, et al.
Sci Adv
. 2023 Dec;
9(48):eadj2801.
PMID: 38039360
The analysis of proteins in the gas phase benefits from detectors that exhibit high efficiency and precise spatial resolution. Although modern secondary electron multipliers already address numerous analytical requirements, additional...
3.
Hua Y, Strauss M, Fisher S, Mauser M, Manchet P, Smacchia M, et al.
JACS Au
. 2023 Oct;
3(10):2790-2799.
PMID: 37885583
The isolation of biomolecules in a high vacuum enables experiments on fragile species in the absence of a perturbing environment. Since many molecular properties are influenced by local electric fields,...
4.
Yu K, Zou Z, Igareta N, Tachibana R, Bechter J, Kohler V, et al.
J Am Chem Soc
. 2023 Jul;
145(30):16621-16629.
PMID: 37471698
Enantioselective C-H amidation offers attractive means to assemble C-N bonds to synthesize high-added value, nitrogen-containing molecules. In recent decades, complementary enzymatic and homogeneous-catalytic strategies for C-H amidation have been reported....
5.
Zaitseva S, Prescimone A, Kohler V
Org Lett
. 2023 Mar;
25(10):1649-1654.
PMID: 36881477
Most tertiary amines with a stereogenic nitrogen center undergo rapid racemization at room temperature. Consequently, the quaternization of amines under dynamic kinetic resolution seems feasible. -Methyl tetrahydroisoquinolines are converted into...
6.
Schatti J, Kohler V, Mayor M, Fein Y, Geyer P, Mairhofer L, et al.
J Mass Spectrom
. 2020 May;
55(6):e4514.
PMID: 32363659
Studies of neutral biomolecules in the gas phase allow for the study of molecular properties in the absence of solvent and charge effects, thus complementing spectroscopic and analytical methods in...
7.
Schatti J, Kriegleder M, Debiossac M, Kerschbaum M, Geyer P, Mayor M, et al.
Chem Commun (Camb)
. 2019 Oct;
55(83):12507-12510.
PMID: 31576386
Charge reduction and neutralization of electro-sprayed peptides are realized by selective gas-phase photocleavage of tailored covalent tags. The concept is demonstrated with four model peptides in positive and negative ion...
8.
Schwizer F, Okamoto Y, Heinisch T, Gu Y, Pellizzoni M, Lebrun V, et al.
Chem Rev
. 2017 Jul;
118(1):142-231.
PMID: 28714313
The incorporation of a synthetic, catalytically competent metallocofactor into a protein scaffold to generate an artificial metalloenzyme (ArM) has been explored since the late 1970's. Progress in the ensuing years...
9.
Liu Z, Lebrun V, Kitanosono T, Mallin H, Kohler V, Haussinger D, et al.
Angew Chem Int Ed Engl
. 2016 Aug;
55(38):11587-90.
PMID: 27529471
Regulation of enzymatic activity is vital to living organisms. Here, we report the development and the genetic optimization of an artificial zymogen requiring the action of a natural protease to...
10.
Okamoto Y, Kohler V, Ward T
J Am Chem Soc
. 2016 Apr;
138(18):5781-4.
PMID: 27100673
Enzymes typically depend on either NAD(P)H or FADH2 as hydride source for reduction purposes. In contrast, organometallic catalysts most often rely on isopropanol or formate to generate the reactive hydride...