Valarie Byford
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Explore the profile of Valarie Byford including associated specialties, affiliations and a list of published articles.
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8
Citations
108
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Recent Articles
1.
Gambhir V, Kim J, Siddiqui S, Taylor M, Byford V, Petrof E, et al.
Immunobiology
. 2011 May;
216(9):988-96.
PMID: 21529994
The vitamin D metabolite, 1,25-(OH)₂D₃, binds the vitamin D receptor (VDR) to exert its regulatory effects at the transcription level. VDR is expressed in professional antigen-presenting cells (pAPCs), such as...
2.
Prosser D, Kaufmann M, OLeary B, Byford V, Jones G
Proc Natl Acad Sci U S A
. 2007 Jul;
104(31):12673-8.
PMID: 17646648
Studies of 25-hydroxyvitamin D(3)-24-hydroxylase (CYP24A1) have demonstrated that it is a bifunctional enzyme capable of the 24-hydroxylation of 1alpha,25-(OH)(2)D(3), leading to the excretory form, calcitroic acid, and 23-hydroxylation, culminating in...
3.
Jones G, Byford V, West S, Masuda S, Ibrahim G, Kaufmann M, et al.
Anticancer Res
. 2006 Aug;
26(4A):2589-95.
PMID: 16886668
Like most pharmaceutical agents, vitamin D analogs are subject to hepatic metabolism by a variety of cytochrome P450 (CYP)-based systems. Metabolism can involve activation as well as inactivation of the...
4.
Jellinck P, Kaufmann M, Gottfried-Blackmore A, Croft G, Byford V, McEwen B, et al.
J Steroid Biochem Mol Biol
. 2005 Oct;
98(1):41-7.
PMID: 16203131
Studies to elucidate the role of dehydroepiandrosterone (DHEA) metabolism in neuroprotection have compared its relative 7-hydroxylation against estrogen formation by way of 4-androstenedione (AD) in various rodent brain cell lines....
5.
Jellinck P, Croft G, McEwen B, Gottfried-Blackmore A, Jones G, Byford V, et al.
J Steroid Biochem Mol Biol
. 2005 Mar;
93(1):81-6.
PMID: 15748836
The rate of aromatization of 4-androstenedione (AD) and 7-hydroxylation of dehydroepiandrosterone (DHEA) by different neuronal cell lines from fetal rat and mouse brain was compared to that of embryonic rat...
6.
Masuda S, Byford V, Arabian A, Sakai Y, Demay M, St-Arnaud R, et al.
Endocrinology
. 2004 Oct;
146(2):825-34.
PMID: 15498883
The 25-hydroxyvitamin D-24-hydroxylase (CYP24A1) plays an important role in regulating concentrations of both the precursor 25-hydroxyvitamin D3 [25(OH)D3] and the hormone 1alpha,25-dihydroxyvitamin D3 [1alpha,25(OH)(2)D3]. Previous studies suggest that Cyp24a1-null mice...
7.
Masuda S, Kaufmann M, Byford V, Gao M, St-Arnaud R, Arabian A, et al.
J Steroid Biochem Mol Biol
. 2004 Jul;
89-90(1-5):149-53.
PMID: 15225763
The development of novel gene expression systems for cytochrome P450s (CYPs) together with a revolution in analytical mass spectrometry with the emergence of liquid chromatography/mass spectrometry (LC/MS) has opened the...
8.
Byford V, Strugnell S, Coldwell R, Schroeder N, Makin H, Knutson J, et al.
Biochim Biophys Acta
. 2002 Jul;
1583(2):151-66.
PMID: 12117559
In this study, we used molecules with either of the structural differences in the side chains of vitamin D(2) and vitamin D(3) to investigate which feature is responsible for the...