Vakul Mohanty
Overview
Explore the profile of Vakul Mohanty including associated specialties, affiliations and a list of published articles.
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Articles
35
Citations
593
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0
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Recent Articles
1.
He S, Tan Y, Ye Q, Gubin M, Rafei H, Peng W, et al.
bioRxiv
. 2025 Mar;
PMID: 40060525
Large scale application of single-cell and spatial omics in models and patient samples has led to the discovery of many novel gene sets, particularly those from an immunotherapeutic context. However,...
2.
Wang Y, Casarin S, Daher M, Mohanty V, Dede M, Shanley M, et al.
bioRxiv
. 2025 Mar;
PMID: 40027823
Adoptive cell therapies (ACT) leverage tumor-immune interactions to cure cancer. Despite promising phase I/II clinical trials of chimeric-antigen-receptor natural killer (CAR-NK) cell therapies, molecular mechanisms and cellular properties required to...
3.
Wang Y, Dede M, Mohanty V, Dou J, Li Z, Chen K
Cell Rep Methods
. 2024 Dec;
4(12):100913.
PMID: 39644902
Decoding cellular state transitions is crucial for understanding complex biological processes in development and disease. While recent advancements in single-cell RNA sequencing (scRNA-seq) offer insights into cellular trajectories, existing tools...
4.
Lyu Y, Kim S, Humphrey E, Nayak R, Guan Y, Liang Q, et al.
Cell
. 2024 Oct;
187(26):7414-7432.e26.
PMID: 39476839
Mammalian retrotransposons constitute 40% of the genome. During tissue regeneration, adult stem cells coordinately repress retrotransposons and activate lineage genes, but how this coordination is controlled is poorly understood. Here,...
5.
Tan Y, Mohanty V, Liang S, Dou J, Ma J, Kim K, et al.
J Bioinform Syst Biol
. 2024 Sep;
6(2):74-81.
PMID: 39301431
We present novoRNABreak, a unified framework for cancer specific novel splice junction and fusion transcript detection in RNA-seq data obtained from human cancer samples. novoRNABreak is based on a local...
6.
Kumar B, Singh A, Basar R, Uprety N, Li Y, Fan H, et al.
Sci Transl Med
. 2024 Sep;
16(764):eadp0004.
PMID: 39259809
Myelodysplastic syndrome and acute myeloid leukemia (AML) belong to a continuous disease spectrum of myeloid malignancies with poor prognosis in the relapsed/refractory setting necessitating novel therapies. Natural killer (NK) cells...
7.
Chomczyk M, Gazzola L, Dash S, Firmanty P, George B, Mohanty V, et al.
Front Pharmacol
. 2024 Aug;
15:1409210.
PMID: 39161899
Acute myeloid leukemia AML), an aggressive malignancy of hematopoietic stem cells, is characterized by the blockade of cell differentiation, uncontrolled proliferation, and cell expansion that impairs healthy hematopoiesis and results...
8.
Shanley M, Daher M, Dou J, Li S, Basar R, Rafei H, et al.
Cancer Cell
. 2024 Aug;
42(8):1450-1466.e11.
PMID: 39137729
Glioblastoma (GBM) is an aggressive brain cancer with limited therapeutic options. Natural killer (NK) cells are innate immune cells with strong anti-tumor activity and may offer a promising treatment strategy...
9.
He S, Gubin M, Rafei H, Basar R, Dede M, Jiang X, et al.
iScience
. 2024 Jul;
27(6):110096.
PMID: 38957791
Recent developments in immunotherapy, including immune checkpoint blockade (ICB) and adoptive cell therapy (ACT), have encountered challenges such as immune-related adverse events and resistance, especially in solid tumors. To advance...
10.
Acharya S, Basar R, Daher M, Rafei H, Li P, Uprety N, et al.
Cancer Discov
. 2024 Jun;
14(10):1879-1900.
PMID: 38900051
Multiple factors in the design of a chimeric antigen receptor (CAR) influence CAR T-cell activity, with costimulatory signals being a key component. Yet, the impact of costimulatory domains on the...