V W Yong
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Explore the profile of V W Yong including associated specialties, affiliations and a list of published articles.
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Articles
112
Citations
3234
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Recent Articles
1.
Mecha M, Yanguas-Casas N, Feliu A, Mestre L, Carrillo-Salinas F, Azcoitia I, et al.
Brain Behav Immun
. 2018 Dec;
77:110-126.
PMID: 30582962
Remyelination is an endogenous process by which functional recovery of damaged neurons is achieved by reinstating the myelin sheath around axons. Remyelination has been documented in multiple sclerosis (MS) lesions...
2.
Koch M, Ilnytskyy Y, Golubov A, Metz L, Yong V, Kovalchuk O
Eur J Neurol
. 2018 Jan;
25(4):651-658.
PMID: 29316044
Background And Purpose: Genetic research in multiple sclerosis (MS) mostly compares patients with MS with healthy controls, but does not differentiate between MS disease courses. We compared peripheral blood gene...
3.
Zhang Y, Metz L, Yong V, Mitchell J
J Neurol Sci
. 2010 Aug;
297(1-2):76-81.
PMID: 20708201
Abnormally decreased deep gray matter (GM) signal intensity on T2-weighted MRI (T2 hypointensity) is associated with brain atrophy and disability progression in patients with multiple sclerosis (MS) and is believed...
4.
Metz L, Li D, Traboulsee A, Myles M, Duquette P, Godin J, et al.
Mult Scler
. 2009 Sep;
15(10):1183-94.
PMID: 19776092
Minocycline is proposed as an add-on therapy to improve the efficacy of glatiramer acetate in relapsing-remitting multiple sclerosis. The effect of minocycline plus glatiramer acetate was evaluated in this double-blind,...
5.
Yong V, Giuliani F, Xue M, Bar-Or A, Metz L
Neurology
. 2007 Jul;
68(22 Suppl 3):S32-7.
PMID: 17548566
Activated T cells, particularly those of the T-helper (Th) 1 subset, have the capacity to kill neurons. Strategies for preventing such damage may include deviation of activated T cells into...
6.
Zabad R, Metz L, Todoruk T, Zhang Y, Mitchell J, Yeung M, et al.
Mult Scler
. 2007 Apr;
13(4):517-26.
PMID: 17463074
Minocycline has immunomodulatory and neuroprotective activities in vitro and in an animal model of multiple sclerosis (MS). We have previously reported that minocycline decreased gadolinium-enhancing activity over six months in...
7.
Wang C, Song J, Song D, Yong V, Shuaib A, Hao C
Cell Death Differ
. 2005 Nov;
13(7):1203-12.
PMID: 16273078
Cyclin-dependent kinase-5 (Cdk5) is required for neuronal survival, but its targets in the apoptotic pathways remain unknown. Here, we show that Cdk5 kinase activity prevents neuronal apoptosis through the upregulation...
8.
McDonald J, McManaman J, Yong V
IDrugs
. 2005 Jul;
4(4):427-42.
PMID: 16015483
Activated cells of the immune system and the biochemical mediators they produce, underlie the pathology and secondary tissue damage in a wide range of diseases and traumas. One approach to...
9.
Yong V
Expert Opin Investig Drugs
. 2005 Jul;
8(3):255-68.
PMID: 15992076
The matrix metalloproteinases (MMPs) are considered to be the physiological mediators of extracellular matrix remodelling. MMPs are involved in a variety of functions and in the nervous system, these include...
10.
Liberto C, Albrecht P, Herx L, Yong V, Levison S
J Neurochem
. 2004 May;
89(5):1092-100.
PMID: 15147501
The prevailing view of the astrocytic response to injury is that reactive astrocytes impede the regenerative process by forming scar tissue. As the levels of many cytokines dramatically increase following...