V S Shankar
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Explore the profile of V S Shankar including associated specialties, affiliations and a list of published articles.
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32
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195
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Recent Articles
11.
Shankar V, Huang C, Adebanjo O, Pazianas M, Zaidi M
Exp Physiol
. 1994 Jul;
79(4):537-45.
PMID: 7946282
Intracellular and extracellular sources of cytosolic [Ca2+] elevation in isolated rat osteoclasts were explored by a comparison of fura-2 signals in response to application of the Ca2+ ionophore, ionomycin, in...
12.
Zaidi M, Bax B, Shankar V, Moonga B, Simon B, Alam A, et al.
Exp Physiol
. 1994 May;
79(3):387-99.
PMID: 8074851
Calcitonin inhibits bone resorption through a direct action on the osteoclast. We report a quantitative analysis of bone resorption by disaggregated rat osteoclasts. We then used our findings to develop...
13.
Adebanjo O, Shankar V, Pazianas M, Zaidi A, Simon B, Huang C, et al.
Biochem Biophys Res Commun
. 1994 Mar;
199(2):742-7.
PMID: 8135818
We report a sensitivity of the osteoclast cell surface Ca2+ receptor to extracellular protons. Freshly isolated rat osteoclasts were exposed to the known agonists of the Ca2+ receptor, Ca2+ and...
14.
Zaidi M, Pazianas M, Shankar V, Bax B, Bax C, Bevis P, et al.
Exp Physiol
. 1993 Nov;
78(6):721-39.
PMID: 8311941
Bone resorption appears to be dependent on a range of processes. It requires an adequate number of osteoclasts to access bone mineral. These osteoclasts must be activated by a mechanism...
15.
Zaidi M, Shankar V, Huang C, Pazianas M, Bloom S
Trends Endocrinol Metab
. 1993 Oct;
4(8):255-9.
PMID: 18407165
Amylin, a 37-amino-acid long single-chain polypeptide, is structurally homologous to calcitonin and calcitonin gene-related peptide (CGRP). The peptide is secreted from pancreatic beta cells and is thought to have an...
16.
Zaidi M, Shankar V, Bax C, Bax B, Bevis P, Pazianas M, et al.
J Bone Miner Res
. 1993 Aug;
8(8):961-7.
PMID: 8213258
Cytosolic [Ca2+] was measured in single osteoclasts using fura-2 in experiments investigating the effects of Ca2+ "receptor" activation using thapsigargin as a means of depleting intracellular Ca2+ stores. Application of...
17.
Bax B, Shankar V, Bax C, Alam A, Zara S, Moonga B, et al.
Exp Physiol
. 1993 Jul;
78(4):517-29.
PMID: 8398105
Ni2+ was used as an extracellular activator of the Ca2+ 'receptor' in order to study the regulation of osteoclast function in vitro. Application of different micromolar concentrations of Ni2+ to...
18.
Zaidi M, Moonga B, Huang C, Towhidul Alam A, Shankar V, Pazianas M, et al.
Biosci Rep
. 1993 Jun;
13(3):175-82.
PMID: 8268425
We report the effects of the tetracycline analogues 4-dedimethylaminotetracycline (CMT-1) and minocycline on osteoclast spreading and motility. Both agents influenced the morphometric descriptor of cell spread area, rho, producing cellular...
19.
Bax C, Shankar V, Towhidul Alam A, Bax B, Moonga B, Huang C, et al.
Biosci Rep
. 1993 Jun;
13(3):169-74.
PMID: 8268424
We report the effects of tetracycline analogues on cytosolic Ca2+ transients resulting from application of ionic nickel (Ni2+), a potent surrogate agonist of the osteoclast Ca2+ "receptor". Preincubation with minocycline...
20.
Pazianas M, Zaidi M, Huang C, Moonga B, Shankar V
Biochem Biophys Res Commun
. 1993 May;
192(3):1100-5.
PMID: 8507183
We demonstrated previously that osteoclasts possess a divalent cation-sensitive "receptor", the Ca2+ receptor. Activation of the Ca2+ receptor by the surrogate cation Ni2+ was shown to elicit an increase in...