V K Pathak
Overview
Explore the profile of V K Pathak including associated specialties, affiliations and a list of published articles.
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41
Citations
985
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Recent Articles
1.
Kearney M, Lee K, Bagni R, Wiegand A, Spindler J, Maldarelli F, et al.
Adv Virol
. 2012 Feb;
2011:272193.
PMID: 22312339
The MLV-related retrovirus, XMRV, was recently identified and reported to be associated with both prostate cancer and chronic fatigue syndrome. At the National Cancer Institute-Frederick, MD (NCI-Frederick), we developed highly...
2.
Mishra O, Varshney K, Usha , Ali Z, Nath G, Pathak V, et al.
Indian J Pediatr
. 2004 Apr;
71(4):301-5.
PMID: 15107509
Objective: To evaluate the humoral and cell mediated immune status of children with empyema thoracis. Methods: Serum IgG, IgA, IgM, Complement C3 assay and cell mediated immunity (CMI) tests were...
3.
Hwang C, Svarovskaia E, Pathak V
Proc Natl Acad Sci U S A
. 2001 Oct;
98(21):12209-14.
PMID: 11593039
We recently proposed a dynamic copy-choice model for retroviral recombination in which a steady state between the rates of polymerization and RNA degradation determines the frequency of reverse transcriptase (RT)...
4.
Hu W, Pathak V
Pharmacol Rev
. 2000 Dec;
52(4):493-511.
PMID: 11121508
During the past decade, gene therapy has been applied to the treatment of disease in hundreds of clinical trials. Various tools have been developed to deliver genes into human cells;...
5.
Halvas E, Svarovskaia E, Pathak V
J Virol
. 2000 Oct;
74(22):10349-58.
PMID: 11044079
Retroviral populations exhibit a high evolutionary potential, giving rise to extensive genetic variation. Error-prone DNA synthesis catalyzed by reverse transcriptase (RT) generates variation in retroviral populations. Structural features within RTs...
6.
Cheslock S, ANDERSON J, Hwang C, Pathak V, Hu W
J Virol
. 2000 Sep;
74(20):9571-9.
PMID: 11000228
Minus-strand DNA transfer, an essential step in retroviral reverse transcription, is mediated by the two repeat (R) regions in the viral genome. It is unclear whether R simply serves as...
7.
Svarovskaia E, Delviks K, Hwang C, Pathak V
J Virol
. 2000 Jul;
74(15):7171-8.
PMID: 10888659
Retroviral reverse transcriptases (RTs) frequently switch templates within the same RNA or between copackaged viral RNAs to generate mutations and recombination. To identify structural elements of murine leukemia virus RT...
8.
ANDERSON J, Pathak V, Hu W
J Virol
. 2000 Jul;
74(15):6953-63.
PMID: 10888634
Reverse transcriptase (RT) switches templates frequently during DNA synthesis; the acceptor template can be the same RNA (intramolecular) or the copackaged RNA (intermolecular). Previous results indicated that intramolecular template switching...
9.
Halvas E, Svarovskaia E, Freed E, Pathak V
J Virol
. 2000 Jun;
74(14):6669-74.
PMID: 10864683
The antiretroviral nucleoside analog 2',3'-dideoxy-3'-thiacytidine (3TC) is a potent inhibitor of wild-type human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT). A methionine-to-valine or methionine-to-isoleucine substitution at residue 184 in...
10.
Halvas E, Svarovskaia E, Pathak V
J Virol
. 1999 Dec;
74(1):312-9.
PMID: 10590119
Error-prone DNA synthesis by retroviral reverse transcriptases (RTs) is a major contributor to variation in retroviral populations. Structural features of retroviral RTs that are important for accuracy of DNA synthesis...