Umberto Aiello
Overview
Explore the profile of Umberto Aiello including associated specialties, affiliations and a list of published articles.
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6
Citations
66
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Recent Articles
1.
Aiello U, Porrua O, Libri D
J Mol Biol
. 2024 Oct;
437(1):168808.
PMID: 39357815
Several machineries concurrently work on the DNA, but among them RNA Polymerases (RNAPs) are the most widespread and active users. The homeostasis of such a busy genomic environment relies on...
2.
Heuze J, Kemiha S, Barthe A, Vilarrubias A, Aouadi E, Aiello U, et al.
EMBO J
. 2023 Oct;
42(23):e113104.
PMID: 37855233
R-loops represent a major source of replication stress, but the mechanism by which these structures impede fork progression remains unclear. To address this question, we monitored fork progression, arrest, and...
3.
Patel H, Coppola S, Pomp W, Aiello U, Brouwer I, Libri D, et al.
Mol Cell
. 2023 May;
83(10):1573-1587.e8.
PMID: 37207624
DNA supercoiling has emerged as a major contributor to gene regulation in bacteria, but how DNA supercoiling impacts transcription dynamics in eukaryotes is unclear. Here, using single-molecule dual-color nascent transcription...
4.
Xie J, Aiello U, Clement Y, Haidara N, Girbig M, Schmitzova J, et al.
Sci Adv
. 2022 Jul;
8(28):eabm9875.
PMID: 35857496
RNA polymerase III (RNAPIII) synthesizes essential and abundant noncoding RNAs such as transfer RNAs. Controlling RNAPIII span of activity by accurate and efficient termination is a challenging necessity to ensure...
5.
Aiello U, Challal D, Wentzinger G, Lengronne A, Appanah R, Pasero P, et al.
Mol Cell
. 2022 Jul;
82(16):2952-2966.e6.
PMID: 35839782
Cellular homeostasis requires the coordination of several machineries concurrently engaged in the DNA. Wide-spread transcription can interfere with other processes, and transcription-replication conflicts (TRCs) threaten genome stability. The conserved Sen1...
6.
Appanah R, Lones E, Aiello U, Libri D, Piccoli G
Cell Rep
. 2020 Feb;
30(7):2094-2105.e9.
PMID: 32075754
DNA replication and RNA transcription compete for the same substrate during S phase. Cells have evolved several mechanisms to minimize such conflicts. Here, we identify the mechanism by which the...