Umber Saleem
Overview
Explore the profile of Umber Saleem including associated specialties, affiliations and a list of published articles.
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16
Citations
639
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Recent Articles
1.
Fuchs M, Burke E, Latic N, Murray S, Murray S, Li H, et al.
Kidney Int
. 2025 Feb;
PMID: 39923962
Chronic kidney disease (CKD) is a global health epidemic that greatly increases mortality due to cardiovascular disease. Left ventricular hypertrophy (LVH) is an important mechanism of cardiac injury in CKD....
2.
Maver A, Zigman T, Rangrez A, Coric M, Homolak J, Saric D, et al.
Cold Spring Harb Mol Case Stud
. 2022 Jul;
PMID: 35840178
Purpose: Dilated cardiomyopathy (DCM) is a primary disorder of the cardiac muscle, characterised by dilatation of the left ventricle and contractile dysfunction. About 50% of DCM cases can be attributed...
3.
Cuello F, Knaust A, Saleem U, Loos M, Raabe J, Mosqueira D, et al.
EMBO Mol Med
. 2021 May;
13(6):e13074.
PMID: 33998164
The phospholamban (PLN) p.Arg14del mutation causes dilated cardiomyopathy, with the molecular disease mechanisms incompletely understood. Patient dermal fibroblasts were reprogrammed to hiPSC, isogenic controls were established by CRISPR/Cas9, and cardiomyocytes...
4.
Mannhardt I, Saleem U, Mosqueira D, Loos M, Ulmer B, Lemoine M, et al.
Stem Cell Reports
. 2020 Oct;
15(4):983-998.
PMID: 33053362
Human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CM) are commercially available, and cardiac differentiation established routine. Systematic evaluation of several control hiPSC-CM is lacking. We investigated 10 different control hiPSC-CM lines and...
5.
Bojkova D, Wagner J, Shumliakivska M, Aslan G, Saleem U, Hansen A, et al.
Cardiovasc Res
. 2020 Sep;
116(14):2207-2215.
PMID: 32966582
Aims: Coronavirus disease 2019 is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and has emerged as a global pandemic. SARS-CoV-2 infection can lead to elevated markers of cardiac...
6.
Shibamiya A, Schulze E, Krauss D, Augustin C, Reinsch M, Schulze M, et al.
Curr Protoc Stem Cell Biol
. 2020 Sep;
55(1):e127.
PMID: 32956561
The reproducibility of stem cell research relies on the constant availability of quality-controlled cells. As the quality of human induced pluripotent stem cells (hiPSCs) can deteriorate in the course of...
7.
Saleem U, van Meer B, Katili P, Mohd Yusof N, Mannhardt I, Krotenberg Garcia A, et al.
Toxicol Sci
. 2020 May;
176(1):103-123.
PMID: 32421822
Animal models are 78% accurate in determining whether drugs will alter contractility of the human heart. To evaluate the suitability of human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) for predictive safety...
8.
Saleem U, Ismaili D, Mannhardt I, Pinnschmidt H, Schulze T, Christ T, et al.
Br J Pharmacol
. 2020 Feb;
177(13):3036-3045.
PMID: 32092149
Background And Purpose: Phosphodiesterases (PDEs) are important regulators of β-adrenoceptor signalling in the heart. While PDE4 is the most important isoform that regulates I and force in rodent cardiomyocytes, the...
9.
Horvath A, Christ T, Koivumaki J, Prondzynski M, Zech A, Spohn M, et al.
Cells
. 2020 Jan;
9(1).
PMID: 31968557
Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) represent an unlimited source of human CMs that could be a standard tool in drug research. However, there is concern whether hiPSC-CMs express...
10.
Saleem U, Mannhardt I, Braren I, Denning C, Eschenhagen T, Hansen A
Stem Cell Reports
. 2020 Jan;
14(2):312-324.
PMID: 31956082
Force measurements in ex vivo and engineered heart tissues are well established. Analysis of calcium transients (CaT) is complementary to force, and the combined analysis is meaningful to the study...