Ulf Landegren
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Explore the profile of Ulf Landegren including associated specialties, affiliations and a list of published articles.
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5550
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Recent Articles
11.
Chen L, Eriksson A, Westrom S, Pandzic T, Lehmann S, Cavelier L, et al.
Nat Commun
. 2022 Jul;
13(1):4033.
PMID: 35821208
Rare tumor-specific mutations in patient samples serve as excellent markers to monitor the course of malignant disease and responses to therapy in clinical routine, and improved assay techniques are needed...
12.
Al-Amin R, Muthelo P, Abdurakhmanov E, Vincke C, Amin S, Muyldermans S, et al.
Anal Chem
. 2022 Jul;
94(28):10054-10061.
PMID: 35786874
High-quality affinity probes are critical for sensitive and specific protein detection, in particular for detection of protein biomarkers in the early phases of disease development. Proximity extension assays (PEAs) have...
13.
Lonn P, Al-Amin R, Doulabi E, Heldin J, Gallini R, Bjorkesten J, et al.
Commun Biol
. 2021 Nov;
4(1):1284.
PMID: 34773084
Protein interactions and posttranslational modifications orchestrate cellular responses to e.g. cytokines and drugs, but it has been difficult to monitor these dynamic events in high-throughput. Here, we describe a semi-automated...
14.
Al-Amin R, Gallant C, Muthelo P, Landegren U
Anal Chem
. 2021 Jul;
93(31):10999-11009.
PMID: 34319715
The ability to monitor target engagement in cellular contexts is a key for successful drug discovery and also valuable in clinical routine. A cellular thermal shift assay (CETSA) provides realistic...
15.
Landegren U, Hammond M
Mol Oncol
. 2020 Oct;
15(6):1715-1726.
PMID: 33012111
Cancer diagnostics based on the detection of protein biomarkers in blood has promising potential for early detection and continuous monitoring of disease. However, the currently available protein biomarkers and assay...
16.
Lindskog C, Backman M, Zieba A, Asplund A, Uhlen M, Landegren U, et al.
J Histochem Cytochem
. 2020 Jul;
68(7):515-529.
PMID: 32602410
Immunohistochemistry (IHC) is the accepted standard for spatial analysis of protein expression in tissues. IHC is widely used for cancer diagnostics and in basic research. The development of new antibodies...
17.
Bjorkesten J, Patil S, Fredolini C, Lonn P, Landegren U
Nucleic Acids Res
. 2020 May;
48(13):e73.
PMID: 32469060
Digital PCR provides high sensitivity and unprecedented accuracy in DNA quantification, but current approaches require dedicated instrumentation and have limited opportunities for multiplexing. Here, we present an isothermal platform for...
18.
Ikebuchi R, Isaac A, Yoshii K, Doulabi E, Lof L, Azimi A, et al.
Biochem Biophys Res Commun
. 2020 Mar;
525(3):714-719.
PMID: 32139125
Host proteins incorporated into virus particles have been reported to contribute to infectivity and tissue-tropism. This incorporation of host proteins is expected to be variable among viral particles, however, protein...
19.
Wu D, Yan J, Shen X, Sun Y, Thulin M, Cai Y, et al.
Nat Commun
. 2019 Aug;
10(1):3854.
PMID: 31451692
Exosomes have been implicated in numerous biological processes, and they may serve as important disease markers. Surface proteins on exosomes carry information about their tissues of origin. Because of the...
20.
Gallant C, Landegren U
FEBS J
. 2019 Apr;
286(8):1442-1444.
PMID: 31012288
Single-cell analysis is impacting biology and medicine by changing the scale and resolution at which we investigate multicellular organisms. A particular, overarching aim of this field is to characterize the...