Tzutzuy Ramirez
Overview
Explore the profile of Tzutzuy Ramirez including associated specialties, affiliations and a list of published articles.
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24
Citations
601
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Recent Articles
1.
Ramirez T, Strigun A, Verlohner A, Huener H, Peter E, Herold M, et al.
Arch Toxicol
. 2017 Oct;
92(2):893-906.
PMID: 28965233
Liver toxicity is a leading systemic toxicity of drugs and chemicals demanding more human-relevant, high throughput, cost effective in vitro solutions. In addition to contributing to animal welfare, in vitro...
2.
Vassallo A, Chiappalone M, De Camargos Lopes R, Scelfo B, Novellino A, Defranchi E, et al.
Neurotoxicology
. 2016 Apr;
60:280-292.
PMID: 27036093
There is a need for methods to screen and prioritize chemicals for potential hazard, including neurotoxicity. Microelectrode array (MEA) systems enable simultaneous extracellular recordings from multiple sites in neural networks...
3.
Ramirez T, Stein N, Aumann A, Remus T, Edwards A, Norman K, et al.
Toxicol In Vitro
. 2016 Jan;
32:278-86.
PMID: 26796489
Several non-animal methods are now available to address the key events leading to skin sensitization as defined by the adverse outcome pathway. The KeratinoSens assay addresses the cellular event of...
4.
Ramirez T, Beken S, Chlebus M, Ellis G, Griesinger C, Jonghe S, et al.
Regul Toxicol Pharmacol
. 2015 Jul;
73(1):210-26.
PMID: 26188116
The European Partnership for Alternative Approaches to Animal Testing (EPAA) convened a workshop Knowledge sharing to facilitate regulatory decision-making. Fifty invited participants from the European Commission, national and European agencies...
5.
Urbisch D, Mehling A, Guth K, Ramirez T, Honarvar N, Kolle S, et al.
Regul Toxicol Pharmacol
. 2014 Dec;
71(2):337-51.
PMID: 25541156
Sensitization, the prerequisite event in the development of allergic contact dermatitis, is a key parameter in both hazard and risk assessments. The pathways involved have recently been formally described in...
6.
Ramirez T, Mehling A, Kolle S, Wruck C, Teubner W, Eltze T, et al.
Toxicol In Vitro
. 2014 Aug;
28(8):1482-97.
PMID: 25172300
Allergic contact dermatitis can develop following repeated exposure to allergenic substances. To date, hazard identification is still based on animal studies as non-animal alternatives have not yet gained global regulatory...
7.
Alepee N, Bahinski A, Daneshian M, De Wever B, Fritsche E, Goldberg A, et al.
ALTEX
. 2014 Jul;
31(4):441-77.
PMID: 25027500
Integrated approaches using different in vitro methods in combination with bioinformatics can (i) increase the success rate and speed of drug development; (ii) improve the accuracy of toxicological risk assessment;...
8.
Ramirez T, Buechse A, Dammann M, Melching-Kollmuss S, Woitkowiak C, van Ravenzwaay B
Regul Toxicol Pharmacol
. 2014 Jul;
70(1):286-96.
PMID: 25017362
Endocrine disrupting compounds (EDCs) of natural or synthetic origin can interfere with the balance of the hormonal system, either by altering hormone production, secretion, transport, or their binding and consequently...
9.
Ramirez T, Daneshian M, Kamp H, Bois F, Clench M, Coen M, et al.
ALTEX
. 2013 May;
30(2):209-25.
PMID: 23665807
Metabolomics, the comprehensive analysis of metabolites in a biological system, provides detailed information about the biochemical/physiological status of a biological system, and about the changes caused by chemicals. Metabolomics analysis...
10.
van Ravenzwaay B, Kolle S, Ramirez T, Kamp H
Toxicol Lett
. 2013 Apr;
223(3):271-9.
PMID: 23558297
In the late 1980s vinclozolin was tested for prenatal developmental toxicity in rats for registration purposes in USA. At 1000mg/kgbw, 95% of all fetuses were female upon visual inspection (ano-genital...