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Tzintzuni Garcia

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Articles 17
Citations 1078
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Recent Articles
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Fonseca T, Garcia T, Fernandes G, Nair T, Bianco A
Nat Commun . 2021 Jul; 12(1):4446. PMID: 34290257
The type 2 deiodinase (D2) in the neonatal liver accelerates local thyroid hormone triiodothyronine (T3) production and expression of T3-responsive genes. Here we show that this surge in T3 permanently...
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Barbeira A, Dickinson S, Bonazzola R, Zheng J, Wheeler H, Torres J, et al.
Nat Commun . 2018 May; 9(1):1825. PMID: 29739930
Scalable, integrative methods to understand mechanisms that link genetic variants with phenotypes are needed. Here we derive a mathematical expression to compute PrediXcan (a gene mapping approach) results using summary...
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Cortese R, Gileles-Hillel A, Khalyfa A, Almendros I, Akbarpour M, Khalyfa A, et al.
Sci Rep . 2017 Feb; 7:43648. PMID: 28240319
Obstructive sleep apnea (OSA) affects 8-10% of the population, is characterized by chronic intermittent hypoxia (CIH), and causally associates with cardiovascular morbidities. In CIH-exposed mice, closely mimicking the chronicity of...
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Wheeler H, Shah K, Brenner J, Garcia T, Aquino-Michaels K, Cox N, et al.
PLoS Genet . 2016 Nov; 12(11):e1006423. PMID: 27835642
Understanding the genetic architecture of gene expression traits is key to elucidating the underlying mechanisms of complex traits. Here, for the first time, we perform a systematic survey of the...
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Shen Y, Chalopin D, Garcia T, Boswell M, Boswell W, Shiryev S, et al.
BMC Genomics . 2016 Jan; 17:37. PMID: 26742787
Background: Xiphophorus fishes are represented by 26 live-bearing species of tropical fish that express many attributes (e.g., viviparity, genetic and phenotypic variation, ecological adaptation, varied sexual developmental mechanisms, ability to...
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Yang K, Boswell M, Walter D, Downs K, Gaston-Pravia K, Garcia T, et al.
Comp Biochem Physiol C Toxicol Pharmacol . 2014 Feb; 163:86-94. PMID: 24556253
Xiphophorus fish and interspecies hybrids represent long-standing models to study the genetics underlying spontaneous and induced tumorigenesis. The recent release of the Xiphophorus maculatus genome sequence will allow global genetic...
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Pabuwal V, Boswell M, Pasquali A, Wise S, Kumar S, Shen Y, et al.
Aquat Toxicol . 2013 Apr; 134-135:74-81. PMID: 23584427
Hexavalent chromium Cr(VI) is known to produce cytotoxic effects in humans and is a highly toxic environmental contaminant. Interestingly, it has been shown that free ranging sperm whales (Phyester macrocephalus)...
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Schartl M, Walter R, Shen Y, Garcia T, Catchen J, Amores A, et al.
Nat Genet . 2013 Apr; 45(5):567-72. PMID: 23542700
Several attributes intuitively considered to be typical mammalian features, such as complex behavior, live birth and malignant disease such as cancer, also appeared several times independently in lower vertebrates. The...
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Shen Y, Garcia T, Pabuwal V, Boswell M, Pasquali A, Beldorth I, et al.
Comp Biochem Physiol Part D Genomics Proteomics . 2012 Dec; 8(1):11-6. PMID: 23201534
In recent years RNA-Seq technology has been used not only to quantify differences in gene expression but also to understand the underlying mechanisms that lead to these differences. Nucleotide sequence...