Tzi Shin Toh
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Explore the profile of Tzi Shin Toh including associated specialties, affiliations and a list of published articles.
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Articles
9
Citations
59
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Recent Articles
1.
Lim S, Toh T, Hor J, Lim J, Lit L, Ahmad-Annuar A, et al.
NPJ Parkinsons Dis
. 2025 Feb;
11(1):34.
PMID: 39988587
LRRK2-related Parkinson's disease (LRRK2-PD) is the most frequent form of monogenic PD worldwide, with important therapeutic opportunities, exemplified by the advancement in LRRK2 kinase inhibition studies/trials. However, many LRRK2 variants,...
2.
Dy Closas A, Tan A, Tay Y, Hor J, Toh T, Lim J, et al.
J Parkinsons Dis
. 2025 Feb;
:1877718X241297715.
PMID: 39973484
Background: The availability of deep brain stimulation (DBS), a highly efficacious treatment for several movement disorders, remains low in developing countries, with scarce data available on utilization and outcomes. Objective:...
3.
Lim S, Tan A, Ahmad-Annuar A, Okubadejo N, Lohmann K, Morris H, et al.
Lancet Neurol
. 2024 Oct;
23(12):1267-1280.
PMID: 39447588
Knowledge on the genetic basis of Parkinson's disease has grown tremendously since the discovery of the first monogenic form, caused by a mutation in α-synuclein, and with the subsequent identification...
4.
Lim S, Pajo A, Dy Closas A, Hor J, Toh T, Ngim S, et al.
Parkinsonism Relat Disord
. 2024 Oct;
130:107162.
PMID: 39406616
Recent studies highlight an over-representation of progressive supranuclear palsy, with atypical features, in South Asians. We offer additional insights, including an over-representation of PSP among Malaysian patients of Indian compared...
5.
Toh K, Toh T, Chua K, Rajakumar P, Lee J, Chong C
Gut Pathog
. 2024 Oct;
16(1):56.
PMID: 39369250
Background: Age-related gut microbial changes have been widely investigated over the past decade. Most of the previous age-related microbiome studies were conducted on the Western population, and the short-read sequencing...
6.
Hor J, Toh T, Lim S, Tan A
J Parkinsons Dis
. 2024 Aug;
14(7):1507-1518.
PMID: 39213091
There is increasing evidence that microbial-based therapies can be useful in people with Parkinson's disease (PD). In this viewpoint, we provide a state-of-the-art review of the clinical and pre-clinical evidence...
7.
Jagota P, Phutrakool P, Kamble N, Huyen Thi Dang T, Aldaajani Z, Hatano T, et al.
Mov Disord Clin Pract
. 2024 Aug;
11(11):1396-1409.
PMID: 39206964
Background: Exercise has been demonstrated to result in improvements in physical function, cognition, and quality of life in People with Parkinson's (PwP) but its adoption is variable. Objectives: To investigate...
8.
Lim S, Tan A, Foo J, Tan Y, Chew E, Ahmad Annuar A, et al.
J Mov Disord
. 2024 Jan;
17(2):213-217.
PMID: 38291878
Lysosomal dysfunction plays an important role in neurodegenerative diseases, including Parkinson's disease (PD) and possibly Parkinson-plus syndromes such as progressive supranuclear palsy (PSP). This role is exemplified by the involvement...
9.
Tay Y, Tan A, Lim J, Lohmann K, Ibrahim K, Abdul Aziz Z, et al.
Parkinsonism Relat Disord
. 2023 May;
111:105399.
PMID: 37209484
Background: About 5-10% of Parkinson's disease (PD) cases are early onset (EOPD), with several genes implicated, including GBA1, PRKN, PINK1, and SNCA. The spectrum and frequency of mutations vary across...
10.
Toh T, Chong C, Lim S, Bowman J, Cirstea M, Lin C, et al.
Parkinsonism Relat Disord
. 2021 Nov;
94:1-9.
PMID: 34844021
Background: Gut microbiome alterations have been reported in Parkinson's disease (PD), but with heterogenous findings, likely due to differences in study methodology and population. We investigated the main microbiome alterations...