Tyler R Huycke
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Explore the profile of Tyler R Huycke including associated specialties, affiliations and a list of published articles.
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14
Citations
375
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Recent Articles
1.
Gill H, Yin S, Nerurkar N, Lawlor J, Lee C, Huycke T, et al.
Dev Cell
. 2024 Aug;
59(21):2834-2849.e9.
PMID: 39116876
Hox transcription factors play crucial roles in organizing developmental patterning across metazoa, but how these factors trigger regional morphogenesis has largely remained a mystery. In the developing gut, Hox genes...
2.
Gill H, Yin S, Lawlor J, Huycke T, Nerurkar N, Tabin C, et al.
Proc Natl Acad Sci U S A
. 2024 Jul;
121(28):e2310992121.
PMID: 38968105
Tissue buckling is an increasingly appreciated mode of morphogenesis in the embryo, but it is often unclear how geometric and material parameters are molecularly determined in native developmental contexts to...
3.
Huycke T, Hakkinen T, Miyazaki H, Srivastava V, Barruet E, McGinnis C, et al.
Cell
. 2024 May;
187(12):3072-3089.e20.
PMID: 38781967
Tissue folds are structural motifs critical to organ function. In the intestine, bending of a flat epithelium into a periodic pattern of folds gives rise to villi, finger-like protrusions that...
4.
Huycke T, Miyazaki H, Hakkinen T, Srivastava V, Barruet E, McGinnis C, et al.
bioRxiv
. 2023 Jul;
PMID: 37425793
Tissue folding generates structural motifs critical to organ function. In the intestine, bending of a flat epithelium into a periodic pattern of folds gives rise to villi, the numerous finger-like...
5.
Huycke T, Gartner Z
Science
. 2022 Jan;
375(6576):26-27.
PMID: 34990228
Engineers point the way toward more complex and homogeneous intestinal organoids.
6.
Srivastava V, Huycke T, Phong K, Gartner Z
Curr Opin Cell Biol
. 2020 Jun;
66:51-58.
PMID: 32535255
The mammary gland is a highly dynamic tissue that undergoes repeated cycles of growth and involution during pregnancy and menstruation. It is also the site from which breast cancers emerge....
7.
Huycke T, Miller B, Gill H, Nerurkar N, Sprinzak D, Mahadevan L, et al.
Cell
. 2019 Sep;
179(1):90-105.e21.
PMID: 31539501
The gastrointestinal tract is enveloped by concentric and orthogonally aligned layers of smooth muscle; however, an understanding of the mechanisms by which these muscles become patterned and aligned in the...
8.
Huycke T, Tabin C
Int J Dev Biol
. 2018 Apr;
62(1-2-3):109-119.
PMID: 29616718
The gastrointestinal tract is an essential system of organs required for nutrient absorption. As a simple tube early in development, the primitive gut is patterned along its anterior-posterior axis into...
9.
Uygur A, Young J, Huycke T, Koska M, Briscoe J, Tabin C
Dev Cell
. 2016 Apr;
37(2):127-35.
PMID: 27093082
Anatomical proportions are robustly maintained in individuals that vary enormously in size, both within a species and between members of related taxa. However, the mechanisms underlying scaling are still poorly...
10.
Shyer A, Huycke T, Lee C, Mahadevan L, Tabin C
Cell
. 2015 Apr;
161(3):569-580.
PMID: 25865482
We address the mechanism by which adult intestinal stem cells (ISCs) become localized to the base of each villus during embryonic development. We find that, early in gut development, proliferating...