Tyler Lopez
Overview
Explore the profile of Tyler Lopez including associated specialties, affiliations and a list of published articles.
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9
Citations
96
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Recent Articles
1.
Arslan S, Garcia F, Guo M, Kellinger M, Kruglyak S, LeVieux J, et al.
Nat Biotechnol
. 2023 May;
42(1):132-138.
PMID: 37231263
We present avidity sequencing, a sequencing chemistry that separately optimizes the processes of stepping along a DNA template and that of identifying each nucleotide within the template. Nucleotide identification uses...
2.
Lee K, Dunn Z, Lopez T, Mustafa Z, Ge X
Biotechnol Bioeng
. 2020 Jul;
117(12):3664-3676.
PMID: 32716053
Matrix metalloproteinase-12 (MMP-12), also known as macrophage elastase, is a potent inflammatory mediator and therefore an important pharmacological target. Clinical trial failures of broad-spectrum compound MMP inhibitors suggested that specificity...
3.
Lopez T, Mustafa Z, Chen C, Lee K, Ramirez A, Benitez C, et al.
Proc Natl Acad Sci U S A
. 2019 Aug;
116(33):16314-16319.
PMID: 31363054
Critical for diverse biological processes, proteases represent one of the largest families of pharmaceutical targets. To inhibit pathogenic proteases with desired selectivity, monoclonal antibodies (mAbs) hold great promise as research...
4.
Lopez T, Ramirez A, Benitez C, Mustafa Z, Pham H, Sanchez R, et al.
Antib Ther
. 2018 Nov;
1(2):55-63.
PMID: 30406213
: Proteases are one of the largest pharmaceutical targets for drug developments. Their dysregulations result in a wide variety of diseases. Because proteolytic networks usually consist of protease family members...
5.
Lopez T, Chuan C, Ramirez A, Chen K, Lorenson M, Benitez C, et al.
Biotechnol Bioeng
. 2018 Aug;
115(11):2673-2682.
PMID: 30102763
Targeting effectual epitopes is essential for therapeutic antibodies to accomplish their desired biological functions. This study developed a competitive dual color fluorescence-activated cell sorting (FACS) to maturate a matrix metalloprotease...
6.
Chen K, Chen C, Lopez T, Radecki K, Bustamante K, Lorenson M, et al.
Oncotarget
. 2018 Jul;
9(50):29431-29444.
PMID: 30034628
Matrix metalloproteinases (MMPs) are considered excellent targets for cancer therapy because of their important roles in multiple aspects of tumor growth and metastatic spread. However, not all MMPs, or even...
7.
Directed Evolution to Engineer Monobody for FRET Biosensor Assembly and Imaging at Live-Cell Surface
Limsakul P, Peng Q, Wu Y, Allen M, Liang J, Remacle A, et al.
Cell Chem Biol
. 2018 Feb;
25(4):370-379.e4.
PMID: 29396288
Monitoring enzymatic activities at the cell surface is challenging due to the poor efficiency of transport and membrane integration of fluorescence resonance energy transfer (FRET)-based biosensors. Therefore, we developed a...
8.
Lopez T, Nam D, Kaihara E, Mustafa Z, Ge X
Biotechnol Bioeng
. 2017 Jan;
114(6):1140-1150.
PMID: 28090632
Matrix metalloproteinase (MMP)-14 is an important target for cancer treatment due to its critical roles in tumor invasion and metastasis. Previous failures of all compound-based broad-spectrum MMP inhibitors in clinical...
9.
Nam D, Fang K, Rodriguez C, Lopez T, Ge X
Protein Eng Des Sel
. 2016 Dec;
30(2):113-118.
PMID: 27986919
Matrix metalloproteinase-14 (MMP-14) plays important roles in cancer metastasis, and the failures of broad-spectrum MMP compound inhibitors in clinical trials suggested selectivity is critical. By grafting an MMP-14 specific inhibition...