Tsing-Bau Chen
Overview
Explore the profile of Tsing-Bau Chen including associated specialties, affiliations and a list of published articles.
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20
Citations
418
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Recent Articles
1.
Eftekhari S, Gaspar R, Roberts R, Chen T, Zeng Z, Villarreal S, et al.
J Comp Neurol
. 2015 Jun;
524(1):90-118.
PMID: 26105175
Functional imaging studies have revealed that certain brainstem areas are activated during migraine attacks. The neuropeptide calcitonin gene-related peptide (CGRP) is associated with activation of the trigeminovascular system and transmission...
2.
Eftekhari S, Salvatore C, Johansson S, Chen T, Zeng Z, Edvinsson L
Brain Res
. 2014 Dec;
1600:93-109.
PMID: 25463029
Calcitonin gene-related peptide (CGRP) receptor antagonists have demonstrated anti-migraine efficacy. One remaining question is where do these blockers act? We hypothesized that the trigeminal ganglion could be one possible site....
3.
Patel M, Gleason A, OMalley S, Connolly B, Suresch D, Virostko J, et al.
PLoS One
. 2014 Sep;
9(9):e106693.
PMID: 25198535
Background: Type 2 diabetes results from failure of the β-cells to compensate for increased insulin demand due to abnormal levels of metabolic factors. The ob/ob(lep-/-) mouse has been extensively studied...
4.
Liu P, Hamill T, Chioda M, Chobanian H, Fung S, Guo Y, et al.
ACS Med Chem Lett
. 2014 Jun;
4(6):509-13.
PMID: 24900701
We report herein the discovery of a fatty acid amide hydrolase (FAAH) positron emission tomography (PET) tracer. Starting from a pyrazole lead, medicinal chemistry efforts directed toward reducing lipophilicity led...
5.
Zhang G, Chen T, Davide J, Tao W, Vanko A, Connolly B, et al.
Mol Imaging Biol
. 2013 Feb;
15(4):431-40.
PMID: 23440602
Purpose: Visualization of the cell cycle in living subjects has long been a big challenge. The present study aimed to noninvasively visualize mitotic arrest of the cell cycle with an...
6.
Zhang G, Chen T, Connolly B, Lin S, Hargreaves R, Vanko A, et al.
Assay Drug Dev Technol
. 2009 Aug;
7(4):391-9.
PMID: 19689207
beta-Galactosidase (beta-gal) (encoded by the lacZ gene) has been widely used as a transgene reporter enzyme. The ability to image lacZ expression in living transgenic animals would further extend the...
7.
Zhang G, Chen T, Hargreaves R, Sur C, Williams Jr D
Nat Protoc
. 2008 May;
3(5):891-9.
PMID: 18451797
We have applied noninvasive optical imaging technology to the in vivo hollow fiber assay, using tumor cell lines in which optical reporters are expressed in response to activation/inhibition of a...
8.
Zhang G, Chen T, Bednar B, Connolly B, Hargreaves R, Sur C, et al.
Neoplasia
. 2007 Sep;
9(8):652-61.
PMID: 17786184
The in vivo hollow fiber assay, in which semipermeable hollow fibers filled with tumor cells, are implanted into animals, was originally developed to screen for anticancer compounds before assessment in...
9.
Ha S, Hey P, Ransom R, Bock M, Su D, Murphy K, et al.
Biochemistry
. 2006 Nov;
45(48):14355-61.
PMID: 17128974
We report the critical residues for the interaction of the kinins with human bradykinin receptor 1 (B1) using site-directed mutagenesis in conjunction with molecular modeling of the binding modes of...
10.
Lindsley C, Zhao Z, Leister W, OBrien J, Lemaire W, Williams Jr D, et al.
ChemMedChem
. 2006 Aug;
1(8):807-11.
PMID: 16902933
No abstract available.