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Trixie Wang

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Recent Articles
1.
Quan D, Wang T, Martinez E, Kim H, Sintchenko V, Britton W, et al.
Eur J Clin Microbiol Infect Dis . 2025 Mar; PMID: 40048098
The significant global impact of tuberculosis (TB) on human health is exacerbated by the increasing prevalence of multi-drug resistant tuberculosis (MDR-TB) and the challenges of novel drug discovery for the...
2.
Lukeman H, Al-Wassiti H, Fabb S, Lim L, Wang T, Britton W, et al.
EBioMedicine . 2025 Feb; 113:105599. PMID: 39955975
Background: Mycobacterium tuberculosis remains the largest infectious cause of mortality worldwide, even with over a century of widespread administration of the only licenced tuberculosis (TB) vaccine, Bacillus Calmette-Guérin (BCG). mRNA...
3.
Stevens M, Hawkins P, Wang T, Payne R, Britton W
Tuberculosis (Edinb) . 2025 Jan; 151:102594. PMID: 39756243
Multi-drug-resistant Mycobacterium tuberculosis is an escalating global health problem, and a strong pipeline of novel compounds is needed to combat rising antimicrobial resistance. Ecumicin is a novel analogue of the...
4.
Howlett T, Kumari S, Ehrman R, Masson J, Izzo L, Wang T, et al.
Adv Healthc Mater . 2024 Dec; :e2402358. PMID: 39648542
A first-in-class vaccine adjuvant delivery system, Mn-ZIF, is developed by incorporating manganese (Mn) into the zinc-containing zeolitic-imidazolate framework-8 (ZIF-8). The mixed metal approach, which allowed for tunable Mn doping, is...
5.
Quan D, Wang T, Martinez E, Kim H, Sintchenko V, Britton W, et al.
J Appl Microbiol . 2024 Oct; 135(10). PMID: 39394664
Background: The enormous burden of tuberculosis (TB) worldwide is a major challenge to human health, but the costs and risks associated with novel drug discovery have limited treatment options for...
6.
Stewart E, Counoupas C, Quan D, Wang T, Petrovsky N, Britton W, et al.
Vaccines (Basel) . 2024 Feb; 12(2). PMID: 38400112
Tuberculosis (TB), caused by , results in approximately 1.6 million deaths annually. BCG is the only TB vaccine currently in use and offers only variable protection; however, the development of...
7.
Hawkins P, Hoi D, Cheung C, Wang T, Quan D, Sasi V, et al.
J Med Chem . 2022 Mar; 65(6):4893-4908. PMID: 35293761
Ohmyungsamycin A and ecumicin are structurally related cyclic depsipeptide natural products that possess activity against (Mtb), the causative agent of tuberculosis (TB). Herein, we describe the design and synthesis of...