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Tracie Profaizer

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Recent Articles
1.
Nandakumar V, Profaizer T, Lozier B, Elgort M, Rychert J, Slev P, et al.
J Appl Lab Med . 2021 Nov; 7(3):698-710. PMID: 34741514
Background: Numerous serology assays are available for detection of SARS-CoV-2 antibodies but are limited in that only 1 or 2 target antigen(s) can be tested at a time. Here, we...
2.
Nandakumar V, Profaizer T, Lozier B, Elgort M, Larragoite E, Williams E, et al.
Arch Pathol Lab Med . 2021 Jun; 145(10):1212-1220. PMID: 34181714
Context.—: Emerging evidence shows correlation between the presence of neutralization antibodies (nAbs) and protective immunity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Currently available commercial serology assays lack the...
3.
Profaizer T, Dibb K, Bethers H, Monds C, Andreasen J, Delgado J, et al.
J Appl Lab Med . 2021 Jun; 6(5):1221-1227. PMID: 34151972
Background: Due to the strong association between ankylosing spondylitis and Human Leukocyte Antigen (HLA)-B27, accurate identification of HLA-B27 is important in the diagnosis of patients with suspected spondyloarthritides. For this...
4.
Profaizer T, Pole A, Monds C, Delgado J, Lazar-Molnar E
Hum Immunol . 2020 Jun; 81(7):354-360. PMID: 32499099
HLA associations have been linked to many diseases and are important for risk assessment of drug hypersensitivity reactions. The increasing number of HLA alleles discovered generated a list of ambiguities...
5.
Profaizer T, Slev P
Clin Chem . 2019 Nov; 66(1):229-238. PMID: 31672859
Background: T-cell receptor excision circles (TREC) and κ-deleting recombination receptor excision circles (KREC) concentrations can be used to assess and diagnose immune deficiencies, monitor thymic and bone marrow immune reconstitution,...
6.
Profaizer T, Kumanovics A
Clin Lab Med . 2018 Nov; 38(4):565-578. PMID: 30420053
Human leukocyte antigen (HLA) allele ambiguities are the result of limitations of current HLA typing methodologies. Ambiguities maybe due to polymorphisms in unsequenced regions of HLA genes or cis/trans variants...
7.
Anderson J, Fuller T, Hawkins J, Brinkman M, Profaizer T, Shaddy R
Transplantation . 2005 Aug; 80(3):414-6. PMID: 16082339
Allografts used in the repair of congenital heart defects in children induce a persistent broad HLA antibody response. We have previously shown that a 3-month course of mycophenolic mofetil (MMF)...
8.
Hooper D, Hawkins J, Fuller T, Profaizer T, Shaddy R
Ann Thorac Surg . 2005 Feb; 79(2):641-4. PMID: 15680851
Background: Circulating human leukocyte antigen (HLA) panel-reactive antibodies (PRA > 10%) have been independently associated with increased risk of rejection and mortality in patients who undergo cardiac transplantation. Cryopreserved allografts...
9.
Shaddy R, Fuller T, Anderson J, Lambert L, Brinkman M, Profaizer T, et al.
Ann Thorac Surg . 2004 Apr; 77(5):1734-9. PMID: 15111175
Background: Valved allografts induce a brisk, broadly reactive human leukocyte antigen (HLA) antibody response in children after implantation. Mycophenolic mofetil (MMF) is a powerful immunosuppressant that inhibits the proliferation of...
10.
Hawkins J, Hillman N, Lambert L, Jones J, Di Russo G, Profaizer T, et al.
J Thorac Cardiovasc Surg . 2003 Jul; 126(1):247-52; discussion 252-3. PMID: 12878962
Background: Recognition of the immunogenicity of standard cryopreserved allografts has led to the development of new decellularized allografts (CryoValve SG; CryoLife, Inc, Kennesaw, Ga). This preliminary study examined the HLA...