Toshifumi Tsujiuchi
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Explore the profile of Toshifumi Tsujiuchi including associated specialties, affiliations and a list of published articles.
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139
Citations
1250
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Recent Articles
1.
Yashiro N, Takai M, Yamamoto M, Kusumoto Y, Nagano S, Taniguchi A, et al.
Adv Biol Regul
. 2024 Dec;
96:101068.
PMID: 39626328
In the center of the solid tumor, abnormal vascular architecture impedes sufficient blood supply, leading to continuous hypoxia and nutrient deprivation for the tumor cells. Lysophosphatidic acid (LPA) receptor signaling...
2.
Yamamoto M, Takai M, Yashiro N, Taniguchi A, Tamura M, Kusumoto Y, et al.
Tissue Cell
. 2024 Aug;
91:102528.
PMID: 39208538
Solid tumors are formed by cancer cells and the surrounding non-cancer stromal cells under hypoxic conditions, collectively referred to as the tumor microenvironment (TME). Lysophosphatidic acid (LPA) receptor (LPA to...
3.
Takai M, Yamamoto M, Yashiro N, Nagano S, Kusumoto Y, Tamura M, et al.
Adv Biol Regul
. 2024 Jul;
93:101042.
PMID: 39024813
Lysophosphatidic acid (LPA) signaling via LPA receptors (LPA to LPA) mediates various aspects of cancer cell behaviors. This study aimed to investigate the variation in intracellular ATP levels and its...
4.
Takai M, Yamamoto M, Yashiro N, Tamura M, Taniguchi A, Nagano S, et al.
Biochem Biophys Res Commun
. 2024 Jun;
727:150322.
PMID: 38945064
The tumor microenvironment (TME) comprises cancer and non-cancerous stromal cells, including fibroblasts. Free fatty acids (FFAs) regulate various biological responses by binding to G protein-coupled FFA receptors (FFARs). In this...
5.
Takai M, Mori S, Honoki K, Tsujiuchi T
J Bioenerg Biomembr
. 2024 Jun;
56(4):475-482.
PMID: 38886303
Lysophosphatidic acid (LPA) is a simple lipid which is endogenously synthesized from lysophosphatidylcholine (LPC) by autotaxin (ATX). LPA mediates a variety of cellular responses through the binding of G protein-coupled...
6.
Takai M, Yamamoto M, Yashiro N, Tsujiuchi T
Pathol Res Pract
. 2024 Jun;
260:155385.
PMID: 38875757
Background: Tamoxifen (TAM) is a selective estrogen receptor modulator and has anti-estrogenic activity. Breast cancer cells acquire drug resistance to TAM as a consequence of long-term treatment. Lysophosphatidic acid (LPA)...
7.
Yamamoto M, Takai M, Yashiro N, Hayasaka H, Tsujiuchi T
Biochem Biophys Res Commun
. 2024 Apr;
715:149982.
PMID: 38676998
The tumor microenvironment is an extremely complex composed of cancer cells and various non-cancer cells, including lymphatic endothelial cells. Lysophosphatidic acid (LPA) receptors (LPA to LPA) activate a variety of...
8.
Ikeda H, Takai M, Yashiro N, Amano Y, Hara K, Yamamoto M, et al.
Pathol Res Pract
. 2024 Apr;
257:155293.
PMID: 38615508
Lysophosphatidic acid (LPA) binds to its specific G protein-coupled LPA receptors (LPA to LPA), resulting in the activation of various cellular functions. LPA receptor-mediated signaling facilitates tumor progression in human...
9.
Honoki K, Tsujiuchi T, Kishi S, Kuniyasu H
J Cancer
. 2024 Mar;
15(7):1786-1804.
PMID: 38434982
There is no doubt that anyone who has participated in cancer care or research has once read the 'Hallmarks of Cancer' papers published by Hanahan and Weinberg in 2001 and...
10.
Ikeda H, Takai M, Tsujiuchi T
Adv Biol Regul
. 2024 Feb;
92:101029.
PMID: 38377635
Lysophosphatidic acid (LPA) is a simple physiological lipid and structurally consists of a fatty, a phosphate and a glycerol. LPA binds to G protein-coupled LPA receptors (LPA to LPA). LPA...