Toru Nishinaka
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Explore the profile of Toru Nishinaka including associated specialties, affiliations and a list of published articles.
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Articles
54
Citations
455
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Recent Articles
1.
Shimizu K, Shindou H, Tomita K, Nishinaka T
Yakugaku Zasshi
. 2025 Mar;
145(3):171-176.
PMID: 40024728
The incidence of type 2 diabetes mellitus (T2DM), a major lifestyle-related disease, is increasing worldwide. T2DM, which accounts for approximately 90-95% of all diabetes mellitus cases, is caused by deficient...
2.
Shimizu K, Ono M, Mikamoto T, Urayama Y, Yoshida S, Hase T, et al.
FASEB J
. 2024 Jan;
38(2):e23425.
PMID: 38226852
Postprandial hyperglycemia is an early indicator of impaired glucose tolerance that leads to type 2 diabetes mellitus (T2DM). Alterations in the fatty acid composition of phospholipids have been implicated in...
3.
Aoe M, Esaki S, Ikejiri M, Ito T, Nagai K, Hatsuda Y, et al.
Pharmacy (Basel)
. 2023 Jan;
11(1).
PMID: 36649026
During the coronavirus disease 2019 (COVID-19) pandemic, online-based learning has become mainstream in many countries, and its learning outcomes have been evaluated. However, various studies have shown that online-based learning...
4.
Shimizu K, Nishimuta S, Fukumura Y, Michinaga S, Egusa Y, Hase T, et al.
PLoS One
. 2022 Sep;
17(9):e0274297.
PMID: 36099304
The liver is the main organ that regulates lipid and glucose metabolism. Ectopic lipid accumulation in the liver impairs insulin sensitivity and glucose metabolism. Lipoprotein lipase (LPL), mainly expressed in...
5.
Endo S, Morikawa Y, Matsunaga T, Hara A, Nishinaka T
J Steroid Biochem Mol Biol
. 2022 Apr;
221:106113.
PMID: 35398259
Most members of the aldo-keto reductase (AKR) 1 C subfamily are hydroxysteroid dehydrogenases (HSDs). Similarly to humans, four genes for AKR1C proteins (AKR1C1-AKR1C4) have been identified in the pig, which...
6.
Endo S, Nishiyama T, Matuoka T, Miura T, Nishinaka T, Matsunaga T, et al.
Chem Biol Interact
. 2021 Sep;
348:109634.
PMID: 34506768
Nonsteroidal anti-inflammatory drugs (NSAIDs) are used worldwide as antipyretic analgesics and agents for rheumatoid arthritis and osteoarthritis, but known to cause damage to the gastrointestinal mucosae as their serious adverse...
7.
Endo S, Matsunaga T, Nishinaka T
Metabolites
. 2021 Jun;
11(6).
PMID: 34063865
AKR1B10 is a human nicotinamide adenine dinucleotide phosphate (NADPH)-dependent reductase belonging to the aldo-keto reductase (AKR) 1B subfamily. It catalyzes the reduction of aldehydes, some ketones and quinones, and interacts...
8.
Shimizu K, Ogiya Y, Yoshinaga K, Kimura H, Michinaga S, Ono M, et al.
Exp Clin Endocrinol Diabetes
. 2021 Mar;
130(4):254-261.
PMID: 33782927
Genome-wide association studies have identified more than 300 loci associated with type 2 diabetes mellitus; however, the mechanisms underlying their role in type 2 diabetes mellitus susceptibility remain largely unknown....
9.
Shimizu K, Sakurai F, Iizuka S, Ono R, Tsukamoto T, Nishimae F, et al.
J Immunol
. 2020 Dec;
206(2):410-421.
PMID: 33277385
Adenovirus (Ad) vector-mediated transduction can cause hepatotoxicity during two phases, at ∼2 and 10 days after administration. Early hepatotoxicity is considered to involve inflammatory cytokines; however, the precise mechanism remains...
10.
Shimizu K, Egusa Y, Nishimuta S, Fukumura Y, Yoshimura M, Inomoto T, et al.
Int J Food Sci Nutr
. 2020 Sep;
72(3):335-347.
PMID: 32862731
Obesity is associated with an increased risk of metabolic abnormalities. The citrus fruit calamondin contains nobiletin and hesperidin, which are involved in lipid metabolism, and vitamin C, which is an...