Tooba Murshedkar
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Explore the profile of Tooba Murshedkar including associated specialties, affiliations and a list of published articles.
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26
Citations
1201
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Recent Articles
1.
Tumbo A, Lorenz F, Yang A, Sefried S, Schindler T, Mpina M, et al.
EBioMedicine
. 2024 Oct;
108:105364.
PMID: 39353279
Background: PfSPZ Vaccine, a promising pre-erythrocytic stage malaria vaccine candidate based on whole, radiation-attenuated Plasmodium falciparum (Pf) sporozoites (SPZ), has proven safe and effective in mediating sterile protection from malaria...
2.
Diawara H, Healy S, Mwakingwe-Omari A, Issiaka D, Diallo A, Traore S, et al.
Lancet Infect Dis
. 2024 Aug;
24(12):1366-1382.
PMID: 39153490
Background: Plasmodium falciparum parasitaemia during pregnancy causes maternal, fetal, and infant mortality. Poor pregnancy outcomes are related to blood-stage parasite sequestration and the ensuing inflammatory response in the placenta, which...
3.
Senkpeil L, Bhardwaj J, Little M, Holla P, Upadhye A, Fusco E, et al.
JCI Insight
. 2024 Apr;
9(11).
PMID: 38687615
A systems analysis was conducted to determine the potential molecular mechanisms underlying differential immunogenicity and protective efficacy results of a clinical trial of the radiation-attenuated whole-sporozoite PfSPZ vaccine in African...
4.
Indrihutami K, Chand K, Fahmia R, Rachmat A, Rahardjani M, Wulandari F, et al.
Am J Trop Med Hyg
. 2024 Mar;
110(5):892-901.
PMID: 38531102
Malaria eradication efforts prioritize safe and efficient vaccination strategies, although none with high-level efficacy against malaria infection are yet available. Among several vaccine candidates, Sanaria® PfSPZ Vaccine and Sanaria PfSPZ-CVac...
5.
Jongo S, Church L, Milando F, Qassim M, Schindler T, Rashid M, et al.
J Clin Invest
. 2024 Jan;
134(6).
PMID: 38194272
BACKGROUNDSanaria PfSPZ Vaccine, composed of attenuated Plasmodium falciparum (Pf) sporozoites (SPZ), protects against malaria. We conducted this clinical trial to assess the safety and efficacy of PfSPZ Vaccine in HIV-positive...
6.
Richie T, Church L, Murshedkar T, Billingsley P, James E, Chen M, et al.
Expert Rev Vaccines
. 2023 Aug;
22(1):964-1007.
PMID: 37571809
Introduction: Malaria, a devastating febrile illness caused by protozoan parasites, sickened 247,000,000 people in 2021 and killed 619,000, mostly children and pregnant women in sub-Saharan Africa. A highly effective vaccine...
7.
Jongo S, Urbano Nsue Ndong Nchama V, Church L, Olotu A, Manock S, Schindler T, et al.
Am J Trop Med Hyg
. 2023 May;
109(1):138-146.
PMID: 37160281
The radiation-attenuated Plasmodium falciparum sporozoites (PfSPZ) Vaccine has demonstrated safety and immunogenicity in 5-month-old to 50-year-old Africans in multiple trials. Except for one, each trial has restricted enrollment to either...
8.
Kc N, Church L, Riyahi P, Chakravarty S, Seder R, Epstein J, et al.
Front Immunol
. 2022 Nov;
13:1006716.
PMID: 36389797
Background: While prior research has shown differences in the risk of malaria infection and sickness between males and females, little is known about sex differences in vaccine-induced immunity to malaria....
9.
Mordmuller B, Sulyok Z, Sulyok M, Molnar Z, Lalremruata A, Lamsfus Calle C, et al.
NPJ Vaccines
. 2022 Aug;
7(1):100.
PMID: 35999221
Immunization with radiation-attenuated Plasmodium falciparum (Pf) sporozoites (SPZ) in PfSPZ Vaccine, has provided better vaccine efficacy (VE) against controlled human malaria infection (CHMI) with the same parasites as in the...
10.
Silva J, Dwivedi A, Moser K, Sissoko M, Epstein J, Healy S, et al.
Nat Commun
. 2022 Jun;
13(1):3390.
PMID: 35697668
Controlled human malaria infection (CHMI) has supported Plasmodium falciparum (Pf) malaria vaccine development by providing preliminary estimates of vaccine efficacy (VE). Because CHMIs generally use Pf strains similar to vaccine...