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Toni Urbanik

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Articles 12
Citations 322
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Recent Articles
1.
Scherr A, Nader L, Xu K, Elssner C, Ridder D, Nichetti F, et al.
Hepatology . 2023 Nov; 80(2):278-294. PMID: 37916976
Background And Aims: HCC is the most common primary liver tumor, with an increasing incidence worldwide. HCC is a heterogeneous malignancy and usually develops in a chronically injured liver. The...
2.
Elssner C, Goeppert B, Longerich T, Scherr A, Stindt J, Nanduri L, et al.
Gastroenterology . 2018 Nov; 156(4):1190-1205.e14. PMID: 30445013
Background & Aims: Cholangiocyte proliferation and ductular reaction contribute to the onset and progression of liver diseases. Little is known about the role of the transcription factor nuclear factor-κB (NF-κB)...
3.
Urbanik T, Koehler B, Wolpert L, Elssner C, Scherr A, Longerich T, et al.
World J Gastroenterol . 2014 Dec; 20(45):17049-64. PMID: 25493017
Aim: To analyze the role of CYLD for receptor-mediated cell death of murine hepatocytes in acute liver injury models. Methods: Hepatocyte cell death in CYLD knockout mice (CYLD(-/-) ) was...
4.
Welte S, Urbanik T, Elssner C, Kautz N, Koehler B, Waldburger N, et al.
PLoS One . 2014 Oct; 9(10):e110591. PMID: 25329885
Background & Aims: The deubiquitinase CYLD removes (K-63)-linked polyubiquitin chains from proteins involved in NF-κB, Wnt/ß-catenin and Bcl-3 signaling. Reduced CYLD expression has been reported in different tumor entities, including...
5.
Koehler B, Scherr A, Lorenz S, Elssner C, Kautz N, Welte S, et al.
PLoS One . 2014 Sep; 9(9):e106571. PMID: 25192188
Despite the fact that new treatment regimes have improved overall survival of patients challenged by colorectal cancer (CRC), prognosis in the metastatic situation is still restricted. The Bcl-2 family of...
6.
Koehler B, Scherr A, Lorenz S, Urbanik T, Kautz N, Elssner C, et al.
PLoS One . 2013 Oct; 8(10):e76446. PMID: 24098503
Migration and invasion of malignant cells are prerequisites for cancer progression and metastasis. The Bcl-2 family of proteins consists of about 25 members and has been extensively studied in the...
7.
Urbanik T, Boger R, Longerich T, Becker K, Ehrenberg K, Hovelmeyer N, et al.
J Hepatol . 2012 Jun; 57(5):995-1003. PMID: 22728872
Background & Aims: CYLD is a tumor suppressor gene that is mutated in familial cylindromatosis, an autosomal dominant predisposition to tumors of skin appendages. Reduced CYLD expression has been observed...
8.
Urbanik T, Kohler B, Boger R, Worns M, Heeger S, Otto G, et al.
Int J Oncol . 2010 Nov; 38(1):121-31. PMID: 21109933
The cylindromatosis gene (CYLD) was identified as a tumor suppressor gene, which is mutated in familial cylindromatosis (Brooke-Spiegler syndrome), an autosomal-dominant predisposition to multiple tumors of the skin appendages. CYLD...
9.
Weber A, Boger R, Vick B, Urbanik T, Haybaeck J, Zoller S, et al.
Hepatology . 2010 Jan; 51(4):1226-36. PMID: 20099303
Unlabelled: Regulation of hepatocellular apoptosis is crucial for liver homeostasis. Increased sensitivity of hepatocytes toward apoptosis results in chronic liver injury, whereas apoptosis resistance is linked to hepatocarcinogenesis and nonresponsiveness...
10.
Koehler B, Urbanik T, Vick B, Boger R, Heeger S, Galle P, et al.
World J Gastroenterol . 2009 Dec; 15(47):5924-35. PMID: 20014456
Aim: To analyze the effect of chemotherapeutic drugs and specific kinase inhibitors, in combination with the death receptor ligand tumor necrosis factor-related apoptosis inducing ligand (TRAIL), on overcoming TRAIL resistance...