Tomoyuki Mashimo
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Explore the profile of Tomoyuki Mashimo including associated specialties, affiliations and a list of published articles.
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20
Citations
2289
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Recent Articles
1.
Vue T, Kollipara R, Borromeo M, Smith T, Mashimo T, Burns D, et al.
Glia
. 2020 Jun;
68(12):2613-2630.
PMID: 32573857
Glioblastomas (GBMs) are incurable brain tumors with a high degree of cellular heterogeneity and genetic mutations. Transcription factors that normally regulate neural progenitors and glial development are aberrantly coexpressed in...
2.
Gao X, Zhang Z, Mashimo T, Shen B, Nyagilo J, Wang H, et al.
Cell Rep
. 2020 Feb;
30(8):2489-2500.e5.
PMID: 32101730
Emerging evidence suggests that crosstalk between glioma cells and the brain microenvironment may influence brain tumor growth. To date, known reciprocal interactions among these cells have been limited to the...
3.
Tiwari V, Mashimo T, An Z, Vemireddy V, Piccirillo S, Askari P, et al.
Magn Reson Med
. 2020 Feb;
84(3):1152-1160.
PMID: 32003035
Purpose: To generate a preclinical model of isocitrate dehydrogenase (IDH) mutant gliomas from glioma patients and design a MRS method to test the compatibility of 2-hydroxyglutarate (2HG) production between the...
4.
Kofuji S, Hirayama A, Eberhardt A, Kawaguchi R, Sugiura Y, Sampetrean O, et al.
Nat Cell Biol
. 2019 Aug;
21(8):1003-1014.
PMID: 31371825
In many cancers, high proliferation rates correlate with elevation of rRNA and tRNA levels, and nucleolar hypertrophy. However, the underlying mechanisms linking increased nucleolar transcription and tumorigenesis are only minimally...
5.
Courtney K, Bezwada D, Mashimo T, Pichumani K, Vemireddy V, Funk A, et al.
Cell Metab
. 2018 Aug;
28(5):793-800.e2.
PMID: 30146487
Clear cell renal cell carcinoma (ccRCC) is the most common form of human kidney cancer. Histological and molecular analyses suggest that ccRCCs have significantly altered metabolism. Recent human studies of...
6.
Pichumani K, Mashimo T, Vemireddy V, Ijare O, Mickey B, Malloy C, et al.
FEBS Lett
. 2017 Oct;
591(21):3548-3554.
PMID: 28963851
Malignant brain tumors are known to utilize acetate as an alternate carbon source in the citric acid cycle for their bioenergetics. C NMR-based isotopomer analysis has been used to measure...
7.
Choi C, Raisanen J, Ganji S, Zhang S, McNeil S, An Z, et al.
J Clin Oncol
. 2017 Mar;
34(33):4030-4039.
PMID: 28248126
Purpose Proton magnetic resonance spectroscopy (MRS) of the brain can detect 2-hydroxyglutarate (2HG), the oncometabolite produced in neoplasms harboring a mutation in the gene coding for isocitrate dehydrogenase ( IDH)....
8.
Singh D, Kollipara R, Vemireddy V, Yang X, Sun Y, Regmi N, et al.
Cell Rep
. 2017 Jan;
18(4):961-976.
PMID: 28122245
Efforts to identify and target glioblastoma (GBM) drivers have primarily focused on receptor tyrosine kinases (RTKs). Clinical benefits, however, have been elusive. Here, we identify an SRY-related box 2 (SOX2)...
9.
Pichumani K, Mashimo T, Vemireddy V, Kovacs Z, Ratnakar J, Mickey B, et al.
Neurochem Int
. 2016 Mar;
97:133-6.
PMID: 27020407
(13)C-enriched compounds are readily metabolized in human malignancies. Fragments of the tumor, acquired by biopsy or surgical resection, may be acid-extracted and (13)C NMR spectroscopy of metabolites such as glutamate,...
10.
Pichumani K, Mashimo T, Baek H, Ratnakar J, Mickey B, DeBerardinis R, et al.
Anal Biochem
. 2015 Apr;
481:4-6.
PMID: 25908561
(13)C NMR (nuclear magnetic resonance) spectroscopy of extracts from patient tumor samples provides rich information about metabolism. However, in isocitrate dehydrogenase (IDH)-mutant gliomas, (13)C labeling is obscured in oncometabolite 2-hydroxyglutaric...