Tomohiro Fujii
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Explore the profile of Tomohiro Fujii including associated specialties, affiliations and a list of published articles.
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Articles
43
Citations
260
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Recent Articles
1.
Watanabe T, Arashida N, Fujii T, Shikida N, Ito K, Shimbo K, et al.
J Med Chem
. 2024 Oct;
67(20):18124-18138.
PMID: 39410752
Antibody-drug conjugates (ADCs) combine cytotoxic payloads with monoclonal antibodies through chemical linkers. Finding linkers that both enhance circulatory stability and enable effective tumor payload release remains a challenge. The conventional...
2.
Nakamura K, Suehiro Y, Hamabe K, Goto A, Hashimoto S, Kunimune Y, et al.
Oncology
. 2024 Sep;
:1-7.
PMID: 39236692
Introduction: As the incidence of gastric cancer (GC) is increasing in East Asia including Japan, a simple blood test for early GC is needed as an alternative to upper gastrointestinal...
3.
Nishioka M, Hamabe K, Kunimune Y, Kodama M, Nakahara Y, Okayama N, et al.
Diagn Microbiol Infect Dis
. 2024 Jul;
110(1):116444.
PMID: 39024933
Human ascariasis is a soil-transmitted helminthiasis and remains a neglected tropical disease. Ascaris suum has the potential to cause cross-infections between humans and pigs. In this study, we present a...
4.
Nishikawa J, Tamura Y, Fujii T, Fukuda S, Yoneda S, Yamaura N, et al.
Int J Mol Sci
. 2024 Jul;
25(13).
PMID: 39000160
222 nm far-ultraviolet (F-UV) light has a bactericidal effect similar to deep-ultraviolet (D-UV) light of about a 260 nm wavelength. The cytotoxic effect of 222 nm F-UV has not been...
5.
Nishikawa J, Fujii T, Fukuda S, Yoneda S, Tamura Y, Shimizu Y, et al.
J Microbiol Immunol Infect
. 2024 Jun;
57(4):533-545.
PMID: 38825404
Background: Periodontal disease is the leading cause of tooth loss, and an association between periodontal disease and non-oral systemic diseases has been shown. Formation of biofilm by periodontal pathogens such...
6.
Matsuda Y, Shikida N, Hatada N, Yamada K, Seki T, Nakahara Y, et al.
Org Lett
. 2024 Apr;
26(27):5597-5601.
PMID: 38639400
A traceless site-selective conjugation method, "AJICAP-M", was developed for native antibodies at sites using Fc-affinity peptides, focusing on Lys248 or Lys288. It produces antibody-drug conjugates (ADCs) with consistent drug-to-antibody ratios,...
7.
Biological Evaluation of Antibody-Drug Conjugates Produced by Tag-Free Lipoate Ligase A Modification
Yamazaki S, Ito K, Aoki T, Arashida N, Watanabe T, Fujii T, et al.
Biochemistry
. 2024 Feb;
63(5):644-650.
PMID: 38350078
The concept of tag-free protein modification has attracted considerable interest in chemical biology because of its flexible and straightforward reaction process. In 2021, a groundbreaking approach using lipoate ligase A...
8.
Fujii T, Ito K, Takahashi K, Aoki T, Takasugi R, Seki T, et al.
ACS Med Chem Lett
. 2023 Dec;
14(12):1767-1773.
PMID: 38116449
Bispecific antibodies (BisAbs) are biotherapeutics that amalgamate the specificities of two distinct antibodies into one molecule, however, their engineering requires genetic modification and remains time-consuming. Therefore, we used AJICAP second-generation...
9.
Fujii T, Matsuda Y
Expert Opin Biol Ther
. 2023 Nov;
23(11):1053-1065.
PMID: 37953519
Introduction: In the field of bioconjugates, the focus on antibody - drug conjugates (ADCs) with novel payloads beyond the traditional categories of potent cytotoxic agents is increasing. These innovative ADCs...
10.
Fujii T, Matsuda Y, Seki T, Shikida N, Iwai Y, Ooba Y, et al.
Bioconjug Chem
. 2023 Mar;
PMID: 36894324
The site-directed chemical conjugation of antibodies remains an area of great interest and active efforts within the antibody-drug conjugate (ADC) community. We previously reported a unique site modification using a...