Tomohiko Makiyama
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Explore the profile of Tomohiko Makiyama including associated specialties, affiliations and a list of published articles.
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21
Citations
102
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Recent Articles
1.
Watanabe Y, Obama T, Makiyama T, Itabe H
Biomedicines
. 2024 Nov;
12(11).
PMID: 39595101
Background: Neutrophils eject their DNA strings and cellular proteins into the extracellular space upon treatment with various stimulants. In the present study, we examined the effects of four major oxidized...
2.
Ohinata H, Phimarn W, Mizuno M, Obama T, Fukuhara K, Makiyama T, et al.
J Clin Biochem Nutr
. 2024 Jul;
75(1):17-23.
PMID: 39070531
Neutrophil extracellular trap (NET) formation is a unique self-defense mechanism of neutrophils; however, it is also involved in many diseases, including atherosclerosis. Resveratrol and catechin are antioxidants with anti-atherosclerotic properties....
3.
Makiyama T, Obama T, Watanabe Y, Chatani M, Azetsu Y, Kawaguchi K, et al.
Exp Cell Res
. 2023 Nov;
433(2):113855.
PMID: 37995922
Intracellular lipid droplets (LDs) are ubiquitous organelles found in many cell types. During mitosis, membranous organelles, including mitochondria, are divided into small pieces and transferred to daughter cells; however, the...
4.
Ohinata H, Obama T, Makiyama T, Watanabe Y, Itabe H
Int J Mol Sci
. 2022 Nov;
23(22).
PMID: 36430470
Neutrophil extracellular traps (NETs) are found in patients with various diseases, including cardiovascular diseases. We previously reported that copper-oxidized low-density lipoprotein (oxLDL) promotes NET formation of neutrophils, and that the...
5.
Makiyama T, Obama T, Watanabe Y, Itabe H
Int J Mol Sci
. 2022 Jun;
23(12).
PMID: 35742827
Lipid droplets (LDs) are intracellular organelles that are ubiquitous in many types of cells. The LD core consists of triacylglycerols (TGs) surrounded by a phospholipid monolayer and surface proteins such...
6.
Higashi S, Makiyama T, Sakane H, Nogami S, Shirataki H
J Cell Sci
. 2021 Dec;
135(1).
PMID: 34897470
In clathrin-independent endocytosis, Hook1, a microtubule- and cargo-tethering protein, participates in sorting of cargo proteins such as CD98 (encoded by SLC3A2) and CD147 (encoded by BSG) into recycling endosomes. However,...
7.
Itabe H, Sawada N, Makiyama T, Obama T
Biomedicines
. 2021 Jul;
9(6).
PMID: 34201176
Oxidative modification of lipoproteins is implicated in the occurrence and development of atherosclerotic lesions. Earlier studies have elucidated on the mechanisms of foam cell formation and lipid accumulation in these...
8.
Sawada N, Obama T, Mizuno M, Fukuhara K, Iwamoto S, Aiuchi T, et al.
Antioxidants (Basel)
. 2020 Oct;
9(11).
PMID: 33114515
Oxidized low-density lipoprotein (oxLDL) and oxidized high-density lipoprotein (oxHDL), known as risk factors for cardiovascular disease, have been observed in plasma and atheromatous plaques. In a previous study, the content...
9.
Aoyagi K, Itakura M, Fukutomi T, Nishiwaki C, Nakamichi Y, Torii S, et al.
Endocrinology
. 2018 Sep;
159(11):3674-3688.
PMID: 30215699
Dysfunctional mitochondria are observed in β-cells of diabetic patients, which are eventually removed by autophagy. Vesicle-associated membrane protein (VAMP)7, a vesicular SNARE protein, regulates autophagosome formation to maintain mitochondrial homeostasis...
10.
Makiyama T, Higashi S, Sakane H, Nogami S, Shirataki H
Exp Cell Res
. 2017 Dec;
362(2):412-423.
PMID: 29225051
Never in mitosis A-related kinase 2A (Nek2A), a centrosomal serine/threonine kinase, is involved in mitotic progression by regulating the centrosome cycle. Particularly, Nek2A is necessary for dissolution of the intercentriole...