Tommy A Karlsen
Overview
Explore the profile of Tommy A Karlsen including associated specialties, affiliations and a list of published articles.
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Articles
16
Citations
355
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Recent Articles
1.
Frerker N, Karlsen T, Stensland M, Nyman T, Rayner S, Brinchmann J
Front Bioeng Biotechnol
. 2023 Mar;
11:1116513.
PMID: 36896010
Focal lesions of articular cartilage give rise to pain and reduced joint function and may, if left untreated, lead to osteoarthritis. Implantation of generated, scaffold-free autologous cartilage discs may represent...
2.
Al-Modawi R, Brinchmann J, Karlsen T
Osteoarthr Cartil Open
. 2022 Dec;
3(3):100189.
PMID: 36474808
Objective: MicroRNA-140-3p is the most prevalent form of canonical miR-140 in native chondrocytes. IsomiRs are sequence variants of microRNAs with potentially distinct functionalities. Here we present functional studies of canonical...
3.
Hanouskova B, Vavrova G, Ambroz M, Bousova I, Karlsen T, Skalova L, et al.
Biochim Biophys Acta Gene Regul Mech
. 2021 Aug;
1864(10):194734.
PMID: 34339889
Glutathione peroxidase 7 (GPx7) acts as an intracellular stress sensor/transmitter and plays an important role in adipocyte differentiation and the prevention of obesity related pathologies. For this reason, finding the...
4.
Frerker N, Karlsen T, Lilledahl M, Brorson S, Tibballs J, Brinchmann J
Cartilage
. 2021 Apr;
13(1_suppl):1237S-1249S.
PMID: 33858229
Objective: Despite new strategies in tissue engineering, cartilage repair remains a major challenge. Our aim is to treat patients with focal lesions of articular cartilage with autologous hyaline cartilage implants...
5.
Karlsen T, Aae T, Brinchmann J
Sci Rep
. 2019 Dec;
9(1):19999.
PMID: 31882820
microRNAs (miRNAs) are small double stranded RNA molecules consisting of two complementary strands called the 5p and 3p arms. Following imprecise processing and/or addition of nucleotides at the ends, miRNA...
6.
Suliman S, Ali H, Karlsen T, Amiaud J, Mohamed-Ahmed S, Layrolle P, et al.
Sci Rep
. 2019 Nov;
9(1):16031.
PMID: 31690774
Therapeutic potential of human bone marrow stromal/stem cells (hBMSC) must be developed using well defined xenogenic-free conditions. hBMSC were isolated from healthy donors (n = 3) using different isolation and...
7.
Al-Modawi R, Brinchmann J, Karlsen T
Mol Ther Nucleic Acids
. 2019 Aug;
17:776-790.
PMID: 31446120
Osteoarthritis (OA) is the most common degenerative joint disease. One of the main pathogenic factors of OA is thought to be inflammation. Other factors associated with OA are dysregulation of...
8.
Idaszek J, Costantini M, Karlsen T, Jaroszewicz J, Colosi C, Testa S, et al.
Biofabrication
. 2019 Jun;
11(4):044101.
PMID: 31151123
Osteochondral (OC) tissue is a biphasic material comprised of articular cartilage integrated atop subchondral bone. Damage to this tissue is highly problematic, owing to its intrinsic inability to regenerate functional...
9.
Karlsen T, Sundaram A, Brinchmann J
Cartilage
. 2019 May;
13(2_suppl):774S-784S.
PMID: 31072202
Objective: To investigate the heterogeneity of expanded chondrocytes used for autologous chondrocyte implantation. Methods: Human articular chondrocytes were expanded for 14 days, sorted into 86 single cells using fluorescence-activated cell...
10.
Karlsen T, Brinchmann J
Exp Cell Res
. 2018 Nov;
374(1):122-127.
PMID: 30496759
Background: Mesenchymal stromal cells (MSCs) can be used in several clinical applications. While MSCs are frequently cultured in fetal bovine serum for in vitro experimentation, human serum supplements are required...