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Tomi Paananen

Explore the profile of Tomi Paananen including associated specialties, affiliations and a list of published articles. Areas
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Articles 15
Citations 115
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Recent Articles
1.
Ndode-Ekane X, Ali I, Santana-Gomez C, Casillas-Espinosa P, Andrade P, Smith G, et al.
Epilepsy Res . 2023 Dec; 199:107263. PMID: 38056191
Objective: Project 1 of the Preclinical Multicenter Epilepsy Bioinformatics Study for Antiepileptogenic Therapy (EpiBioS4Rx) consortium aims to identify preclinical biomarkers for antiepileptogenic therapies following traumatic brain injury (TBI). The international...
2.
Ndode-Ekane X, Ali I, Santana-Gomez C, Andrade P, Immonen R, Casillas-Espinosa P, et al.
Epilepsia . 2023 Dec; 65(2):511-526. PMID: 38052475
Objective: This study was undertaken to assess reproducibility of the epilepsy outcome and phenotype in a lateral fluid percussion model of posttraumatic epilepsy (PTE) across three study sites. Methods: A...
3.
Bhagavatula S, Cabeen R, Harris N, Grohn O, Wright D, Garner R, et al.
Epilepsy Res . 2023 Aug; 195:107201. PMID: 37562146
Preclinical MRI studies have been utilized for the discovery of biomarkers that predict post-traumatic epilepsy (PTE). However, these single site studies often lack statistical power due to limited and homogeneous...
4.
Manninen E, Chary K, De Feo R, Hamalainen E, Andrade P, Paananen T, et al.
Biomedicines . 2022 Nov; 10(11). PMID: 36359242
It is necessary to develop reliable biomarkers for epileptogenesis and cognitive impairment after traumatic brain injury when searching for novel antiepileptogenic and cognition-enhancing treatments. We hypothesized that a multiparametric magnetic...
5.
Ndode-Ekane X, Immonen R, Hamalainen E, Manninen E, Andrade P, Ciszek R, et al.
Biomedicines . 2022 Sep; 10(9). PMID: 36140398
Brain atrophy induced by traumatic brain injury (TBI) progresses in parallel with epileptogenesis over time, and thus accurate placement of intracerebral electrodes to monitor seizure initiation and spread at the...
6.
Yasmin A, Pitkanen A, Andrade P, Paananen T, Grohn O, Immonen R
Brain Struct Funct . 2021 Nov; 227(1):145-158. PMID: 34757444
Ventricular enlargement is one long-term consequence of a traumatic brain injury, and a risk factor for memory disorders and epilepsy. One underlying mechanisms of the chronic ventricular enlargement is disturbed...
7.
Manninen E, Chary K, Lapinlampi N, Andrade P, Paananen T, Sierra A, et al.
Epilepsia . 2021 Jul; 62(8):1852-1864. PMID: 34245005
Objective: To identify magnetic resonance imaging (MRI) biomarkers for post-traumatic epilepsy. Methods: The EPITARGET (Targets and biomarkers for antiepileptogenesis, epitarget.eu) animal cohort completing T relaxation and diffusion tensor MRI follow-up...
8.
Lapinlampi N, Andrade P, Paananen T, Hamalainen E, Ndode-Ekane X, Puhakka N, et al.
Epilepsia . 2020 Aug; 61(9):2035-2052. PMID: 32786029
Objective: To identify postinjury physiologic, behavioral, and cognitive biomarkers for posttraumatic epilepsy to enrich study populations for long-term antiepileptogenesis studies. Methods: The EPITARGET cohort with behavioral follow-up and 1-month 24/7...
9.
Manninen E, Chary K, Lapinlampi N, Andrade P, Paananen T, Sierra A, et al.
J Neurotrauma . 2020 May; 37(23):2580-2594. PMID: 32349620
Prognostic biomarkers for post-injury outcome are necessary for the development of neuroprotective and antiepileptogenic treatments for traumatic brain injury (TBI). We hypothesized that T relaxation magnetic resonance imaging (MRI) predicts...
10.
Pitkanen A, Paananen T, Kyyriainen J, Gupta S, Heiskanen M, Vuokila N, et al.
Epilepsy Behav . 2020 Apr; 121(Pt B):107080. PMID: 32317161
A biomarker is a characteristic that can be objectively measured as an indicator of normal biologic processes, pathogenic processes, or responses to an exposure or intervention, including therapeutic interventions. Biomarker...