Tomasz Wlodarski
Overview
Explore the profile of Tomasz Wlodarski including associated specialties, affiliations and a list of published articles.
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14
Citations
285
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Recent Articles
1.
Streit J, Bukvin I, Chan S, Bashir S, Woodburn L, Wlodarski T, et al.
Nature
. 2024 Aug;
633(8028):232-239.
PMID: 39112704
Most proteins fold during biosynthesis on the ribosome, and co-translational folding energetics, pathways and outcomes of many proteins have been found to differ considerably from those in refolding studies. The...
2.
Wlodarski T, Streit J, Mitropoulou A, Cabrita L, Vendruscolo M, Christodoulou J
Sci Rep
. 2024 Aug;
14(1):18149.
PMID: 39103467
Cryogenic electron microscopy (cryo-EM) has emerged as a powerful method for the determination of structures of complex biological molecules. The accurate characterisation of the dynamics of such systems, however, remains...
3.
Ahn M, Wlodarski T, Mitropoulou A, Chan S, Sidhu H, Plessa E, et al.
Nat Commun
. 2022 Sep;
13(1):5441.
PMID: 36114226
No abstract available.
4.
Chan S, Wlodarski T, Streit J, Cassaignau A, Woodburn L, Ahn M, et al.
Nat Chem
. 2022 Aug;
14(10):1165-1173.
PMID: 35927328
Co-translational folding is crucial to ensure the production of biologically active proteins. The ribosome can alter the folding pathways of nascent polypeptide chains, yet a structural understanding remains largely inaccessible...
5.
Ahn M, Wlodarski T, Mitropoulou A, Chan S, Sidhu H, Plessa E, et al.
Nat Commun
. 2022 Jul;
13(1):4243.
PMID: 35869078
Co-translational folding is a fundamental process for the efficient biosynthesis of nascent polypeptides that emerge through the ribosome exit tunnel. To understand how this process is modulated by the shape...
6.
Deckert A, Cassaignau A, Wang X, Wlodarski T, Chan S, Waudby C, et al.
Proc Natl Acad Sci U S A
. 2021 Dec;
118(52).
PMID: 34930833
In the cell, the conformations of nascent polypeptide chains during translation are modulated by both the ribosome and its associated molecular chaperone, trigger factor. The specific interactions that underlie these...
7.
Burridge C, Waudby C, Wlodarski T, Cassaignau A, Cabrita L, Christodoulou J
Chem Sci
. 2021 Nov;
12(39):13120-13126.
PMID: 34745542
The folding of many proteins can begin during biosynthesis on the ribosome and can be modulated by the ribosome itself. Such perturbations are generally believed to be mediated through interactions...
8.
Cassaignau A, Wlodarski T, Chan S, Woodburn L, Bukvin I, Streit J, et al.
Nat Chem
. 2021 Oct;
13(12):1214-1220.
PMID: 34650236
Most proteins begin to fold during biosynthesis on the ribosome. It has been suggested that interactions between the emerging polypeptide and the ribosome surface might allow the ribosome itself to...
9.
Waudby C, Wlodarski T, Karyadi M, Cassaignau A, Chan S, Wentink A, et al.
Proc Natl Acad Sci U S A
. 2018 Sep;
115(39):9744-9749.
PMID: 30201720
Cotranslational folding (CTF) is a fundamental molecular process that ensures efficient protein biosynthesis and minimizes the formation of misfolded states. However, the complexity of this process makes it extremely challenging...
10.
Redondo R, de Vladar H, Wlodarski T, Bollback J
J R Soc Interface
. 2017 Jan;
14(126).
PMID: 28053111
Viral capsids are structurally constrained by interactions among the amino acids (AAs) of their constituent proteins. Therefore, epistasis is expected to evolve among physically interacting sites and to influence the...