Tomas Kubelka
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Explore the profile of Tomas Kubelka including associated specialties, affiliations and a list of published articles.
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12
Citations
65
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Recent Articles
1.
Wanek A, Menarini L, Giatti F, Kubelka T, Consoli F, Funaro C, et al.
Int J Pharm
. 2024 Apr;
656:124100.
PMID: 38609059
Transferring an existing marketed pharmaceutical product from batch to continuous manufacturing (CM) without changes in regulatory registration is a challenging task in the pharmaceutical industry. Continuous manufacturing can provide an...
2.
Lyytikainen J, Stasiak P, Kubelka T, Bogaerts I, Wanek A, Stynen B, et al.
Eur J Pharm Biopharm
. 2024 Apr;
199:114278.
PMID: 38583787
The transfer from batch-based to continuous tablet manufacturing increases the quality and efficiency of processes. Nonetheless, as in the development of a batch process, the continuous process design requires optimization...
3.
Lyytikainen J, Kyllonen S, Ervasti T, Komulainen E, Pekarek T, Sluneckova J, et al.
Int J Pharm
. 2023 Oct;
647:123509.
PMID: 37832703
As is the case with batch-based tableting processes, continuous tablet manufacturing can be conducted by direct compression or with a granulation step such as dry or wet granulation included in...
4.
Lyytikainen J, Stasiak P, Kubelka T, Olenius T, Korhonen O, Ketolainen J, et al.
Int J Pharm
. 2022 Nov;
628:122355.
PMID: 36341918
Continuous tablet manufacturing is a competitive option to replace the traditional batch manufacturing approach. The aim of this study was to evaluate technology transfer from batch-based direct compression of a...
5.
Jires J, Dousa M, Gibala P, Kubelka T
J Pharm Biomed Anal
. 2022 Jun;
218:114872.
PMID: 35696937
The possibility of N-Nitrosation in the absence of nitrosating agents was studied on model solutions and film coated tablets containing metformin. N-nitrosodimethylamine (NDMA) and N-nitrosation precursors (dimethylamine and nitrites) were...
6.
Jires J, Kalasek S, Gibala P, Rudovsky J, Dousa M, Kubelka T, et al.
J Pharm Biomed Anal
. 2021 Jan;
195:113877.
PMID: 33422831
An effective analytical method for the quantification of N-nitrosodimethylamine (NDMA) using a liquid chromatography coupled with tandem mass spectrometry was developed and applied to a process optimization study of the...
7.
Jagtap P, Kubelka T, Soni K, Will C, Garg D, Sippel C, et al.
Nat Commun
. 2020 Nov;
11(1):5621.
PMID: 33159082
Interactions between U2AF homology motifs (UHMs) and U2AF ligand motifs (ULMs) play a crucial role in early spliceosome assembly in eukaryotic gene regulation. UHM-ULM interactions mediate heterodimerization of the constitutive...
8.
Mariappan A, Soni K, Schorpp K, Zhao F, Minakar A, Zheng X, et al.
EMBO J
. 2018 Dec;
38(2).
PMID: 30530478
Centrosome amplification is a hallmark of human cancers that can trigger cancer cell invasion. To survive, cancer cells cluster amplified extra centrosomes and achieve pseudobipolar division. Here, we set out...
9.
Dousa M, Slavikova M, Kubelka T, cerny J, Gibala P, Zezula J
J Pharm Biomed Anal
. 2017 Nov;
149:214-224.
PMID: 29126083
An HPLC method with UV and electrospray ionization - mass spectrometry (ESI-MS) detection was developed for the separation and determination of obeticholic acid (OBE) and its related compounds in development...
10.
Sedova P, Brown R, Zvolsky M, Kadlecova P, Bryndziar T, Kubelka T, et al.
J Stroke Cerebrovasc Dis
. 2016 Dec;
26(5):979-986.
PMID: 27955808
Background: Contemporary stroke incidence data are not available in some countries and regions, including in Eastern Europe. Based on previous validation of the accuracy of the National Registry of Hospitalized...