Tom Jaspers
Overview
Explore the profile of Tom Jaspers including associated specialties, affiliations and a list of published articles.
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Articles
12
Citations
498
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0
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Recent Articles
1.
Cuypers M, Jaspers T, Clerckx J, Leekens S, Cawthorne C, Bormans G, et al.
Fluids Barriers CNS
. 2025 Jan;
22(1):11.
PMID: 39885527
Background: Therapeutic antibodies for the treatment of neurological disease show great potential, but their applications are rather limited due to limited brain exposure. The most well-studied approach to enhance brain...
2.
Libe-Philippot B, Lejeune A, Wierda K, Louros N, Erkol E, Vlaeminck I, et al.
Cell
. 2023 Dec;
186(26):5766-5783.e25.
PMID: 38134874
The enhanced cognitive abilities characterizing the human species result from specialized features of neurons and circuits. Here, we report that the hominid-specific gene LRRC37B encodes a receptor expressed in human...
3.
Rue L, Jaspers T, Degors I, Noppen S, Schols D, De Strooper B, et al.
Pharmaceutics
. 2023 Jun;
15(6).
PMID: 37376196
The blood-brain barrier (BBB), while being the gatekeeper of the central nervous system (CNS), is a bottleneck for the treatment of neurological diseases. Unfortunately, most of the biologicals do not...
4.
Wouters Y, Jaspers T, Rue L, Serneels L, De Strooper B, Dewilde M
Fluids Barriers CNS
. 2022 Oct;
19(1):79.
PMID: 36192747
Background: The blood brain barrier (BBB) limits the therapeutic perspective for central nervous system (CNS) disorders. Previously we found an anti-mouse transferrin receptor (TfR) VHH (Nb62) that was able to...
5.
Shah D, Gsell W, Wahis J, Luckett E, Jamoulle T, Vermaercke B, et al.
Cell Rep
. 2022 Aug;
40(8):111280.
PMID: 36001964
Dysfunctions of network activity and functional connectivity (FC) represent early events in Alzheimer's disease (AD), but the underlying mechanisms remain unclear. Astrocytes regulate local neuronal activity in the healthy brain,...
6.
Prior R, Verschoren S, Vints K, Jaspers T, Rossaert E, Klingl Y, et al.
Mol Neurobiol
. 2022 Mar;
59(6):3414-3430.
PMID: 35320455
Charcot-Marie-Tooth disease (CMT) is the most common inherited peripheral neuropathy, with currently no effective treatment or cure. CMT1A is caused by a duplication of the PMP22 gene, which leads to...
7.
Custers M, Wouters Y, Jaspers T, De Bundel D, Dewilde M, Van Eeckhaut A, et al.
Anal Chim Acta
. 2021 Sep;
1178:338803.
PMID: 34482878
The use of biologics in the therapeutic landscape has increased exponentially since the last 3 decades. Nevertheless, patients with central nervous system (CNS) related disorders could not yet benefit from...
8.
Rossaert E, Pollari E, Jaspers T, Van Helleputte L, Jarpe M, Van Damme P, et al.
Acta Neuropathol Commun
. 2019 Jul;
7(1):107.
PMID: 31277703
Dysregulation of epigenetic mechanisms is emerging as a central event in neurodegenerative disorders, including amyotrophic lateral sclerosis (ALS). In many models of neurodegeneration, global histone acetylation is decreased in the...
9.
Van Helleputte L, Kater M, Cook D, Eykens C, Rossaert E, Haeck W, et al.
Neurobiol Dis
. 2017 Dec;
111:59-69.
PMID: 29197621
As cancer is becoming more and more a chronic disease, a large proportion of patients is confronted with devastating side effects of certain anti-cancer drugs. The most common neurological complications...
10.
Boeynaems S, Bogaert E, Kovacs D, Konijnenberg A, Timmerman E, Volkov A, et al.
Mol Cell
. 2017 Mar;
65(6):1044-1055.e5.
PMID: 28306503
Liquid-liquid phase separation (LLPS) of RNA-binding proteins plays an important role in the formation of multiple membrane-less organelles involved in RNA metabolism, including stress granules. Defects in stress granule homeostasis...