Toby J Athersuch
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Explore the profile of Toby J Athersuch including associated specialties, affiliations and a list of published articles.
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33
Citations
758
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Recent Articles
1.
Richards S, Bradshaw P, Johnson C, Stachulski A, Athersuch T, Nicholson J, et al.
J Pharm Biomed Anal
. 2024 May;
246:116238.
PMID: 38805849
Drugs and drug metabolites containing a carboxylic-acid moiety can undergo in vivo conjugation to form 1-β-O-acyl-glucuronides (1-β-O-AGs). In addition to hydrolysis, these conjugates can undergo spontaneous acyl migration, and anomerisation...
2.
Perez-Trujillo M, Athersuch T
Molecules
. 2021 Jun;
26(11).
PMID: 34072383
Nuclear magnetic resonance (NMR) spectroscopy remains one of the core analytical platforms for metabolomics, providing complementary chemical information to others, such as mass spectrometry, and offering particular advantages in some...
3.
Kuhn L, Motiram-Corral K, Athersuch T, Parella T, Perez-Trujillo M
Angew Chem Int Ed Engl
. 2020 Sep;
59(52):23615-23619.
PMID: 32959941
Chirality plays a fundamental role in nature, but its detection and quantification still face many limitations. To date, the enantiospecific analysis of mixtures necessarily requires prior separation of the individual...
4.
Bradshaw P, Athersuch T, Stachulski A, Wilson I
Drug Discov Today
. 2020 Jul;
25(9):1639-1650.
PMID: 32681884
Acyl glucuronidation is a common metabolic fate for acidic drugs and their metabolites and, because these metabolites are reactive, they have been linked to adverse drug reactions (ADRs) and drug...
5.
Bradshaw P, Richards S, Wilson I, Stachulski A, Lindon J, Athersuch T
Org Biomol Chem
. 2020 Feb;
18(7):1389-1401.
PMID: 32002533
Acyl glucuronide metabolites have been implicated in the toxicity of several carboxylic acid-containing drugs, and the rate of their degradation via intramolecular transacylation and hydrolysis has been associated with the...
6.
Brake dust exposure exacerbates inflammation and transiently compromises phagocytosis in macrophages
Selley L, Schuster L, Marbach H, Forsthuber T, Forbes B, Gant T, et al.
Metallomics
. 2020 Jan;
12(3):371-386.
PMID: 31915771
Studies have emphasised the importance of combustion-derived particles in eliciting adverse health effects, especially those produced by diesel vehicles. In contrast, few investigations have explored the potential toxicity of particles...
7.
Lau C, Siskos A, Maitre L, Robinson O, Athersuch T, Want E, et al.
BMC Med
. 2018 Nov;
16(1):202.
PMID: 30404627
Background: Environment and diet in early life can affect development and health throughout the life course. Metabolic phenotyping of urine and serum represents a complementary systems-wide approach to elucidate environment-health...
8.
Athersuch T, Antoine D, Boobis A, Coen M, Daly A, Possamai L, et al.
Toxicol Res (Camb)
. 2018 Aug;
7(3):347-357.
PMID: 30090586
After over 60 years of therapeutic use in the UK, paracetamol (acetaminophen, -acetyl--aminophenol, APAP) remains the subject of considerable research into both its mode of action and toxicity. The pharmacological...
9.
Vermeulen R, Hosnijeh F, Bodinier B, Portengen L, Liquet B, Garrido-Manriquez J, et al.
Int J Cancer
. 2018 Apr;
143(6):1335-1347.
PMID: 29667176
Recent prospective studies have shown that dysregulation of the immune system may precede the development of B-cell lymphomas (BCL) in immunocompetent individuals. However, to date, the studies were restricted to...
10.
Jain P, Vineis P, Liquet B, Vlaanderen J, Bodinier B, van Veldhoven K, et al.
J Epidemiol Community Health
. 2018 Mar;
72(7):564-571.
PMID: 29563153
Epidemiological studies provide evidence that environmental exposures may affect health through complex mixtures. Formal investigation of the effect of exposure mixtures is usually achieved by modelling interactions, which relies on...