Tobias Spielmann
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Explore the profile of Tobias Spielmann including associated specialties, affiliations and a list of published articles.
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74
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2290
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Recent Articles
1.
Nerlich C, Tiedjens F, Hertel R, Henke B, Hauer S, Panitzsch L, et al.
J Med Chem
. 2024 Oct;
67(20):18368-18383.
PMID: 39361938
Inhibition of the lactate transporter PfFNT is a valid novel mode of action against malaria parasites. Current pyridine-substituted pentafluoro-3-hydroxy-pent-2-en-1-ones act as substrate analogs with submicromolar EC in vitro, and >99.7%...
2.
Sabitzki R, Rossmann A, Schmitt M, Flemming S, Guillen-Samander A, Behrens H, et al.
PLoS Biol
. 2024 May;
22(5):e3002639.
PMID: 38820535
Vesicular trafficking, including secretion and endocytosis, plays fundamental roles in the unique biology of Plasmodium falciparum blood-stage parasites. Endocytosis of host cell cytosol (HCC) provides nutrients and room for parasite...
3.
Behrens H, Spielmann T
Sci Rep
. 2024 May;
14(1):10527.
PMID: 38719885
Plasmodium falciparum, the causative agent of malaria, poses a significant global health challenge, yet much of its biology remains elusive. A third of the genes in the P. falciparum genome...
4.
Behrens H, Schmidt S, Henshall I, Lopez-Barona P, Peigney D, Sabitzki R, et al.
mBio
. 2024 May;
15(6):e0198123.
PMID: 38700363
Importance: Parasites with lowered sensitivity to artemisinin-based drugs are becoming widespread. However, even in these "resistant" parasites not all parasites survive treatment. We found that the proportion of surviving parasites...
5.
Schmidt S, Wichers-Misterek J, Behrens H, Birnbaum J, Henshall I, Droge J, et al.
PLoS Pathog
. 2023 Dec;
19(12):e1011814.
PMID: 38039338
Single amino acid changes in the parasite protein Kelch13 (K13) result in reduced susceptibility of P. falciparum parasites to artemisinin and its derivatives (ART). Recent work indicated that K13 and...
6.
Henshall I, Spielmann T
Trends Parasitol
. 2023 Sep;
39(11):936-944.
PMID: 37716852
Nutrient import and waste efflux are critical dependencies for intracellular Plasmodium falciparum parasites. Nutrient transport proteins are often lineage specific and can provide unique targets for antimalarial drug development. P....
7.
Davies H, Bergmann B, Walloch P, Nerlich C, Hansen C, Wittlin S, et al.
Antimicrob Agents Chemother
. 2023 Jul;
67(8):e0035623.
PMID: 37428074
Malaria parasites in the blood stage express a single transmembrane transport protein for the release of the glycolytic end product l-lactate/H from the cell. This transporter is a member of...
8.
Kimmel J, Schmitt M, Sinner A, Jansen P, Mainye S, Ramon-Zamorano G, et al.
Cell Syst
. 2023 Jan;
14(1):9-23.e7.
PMID: 36657393
Taxon-specific proteins are key determinants defining the biology of all organisms and represent prime drug targets in pathogens. However, lacking comparability with proteins in other lineages makes them particularly difficult...
9.
Kehrer J, Pietsch E, Heinze J, Spielmann T, Frischknecht F
J Cell Sci
. 2022 Dec;
136(1).
PMID: 36511329
Malaria is a devastating mosquito-borne parasitic disease that manifests when Plasmodium parasites replicate within red blood cells. During the development within the red blood cell, the parasite digests hemoglobin and...
10.
Wichers J, Mesen-Ramirez P, Fuchs G, Yu-Strzelczyk J, Stacker J, von Thien H, et al.
mBio
. 2022 Apr;
13(2):e0062322.
PMID: 35404116
Membrane transport proteins perform crucial roles in cell physiology. The obligate intracellular parasite Plasmodium falciparum, an agent of human malaria, relies on membrane transport proteins for the uptake of nutrients...