Tobias E Larsson
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Explore the profile of Tobias E Larsson including associated specialties, affiliations and a list of published articles.
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76
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2954
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Recent Articles
1.
Lindberg K, Ovchinnikova O, Moor M, Pirault J, Ketelhuth D, Olauson H, et al.
Atherosclerosis
. 2025 Mar;
403:119158.
PMID: 40054115
Introduction: Components of both the innate and adaptive immune system impact on arterial walls in atherosclerosis. Fibroblast growth factor-23 (FGF23) is a phosphate regulating hormone linked to cardiovascular disease (CVD)...
2.
Nordstrom J, Wennberg L, Nowak G, Larsson T, Thuresson S, Reusch M
Transplant Direct
. 2024 Nov;
10(12):e1727.
PMID: 39534758
Background: RMC-035 is a modified version of alpha-1-microglobulin, an endogenous protein developed as a renoprotective agent. Its intended use is to reduce the risk of irreversible loss of kidney function...
3.
Zarbock A, Larsson T, Noiseux N, Mazer C, Bohm J, Laflamme M, et al.
EClinicalMedicine
. 2024 Sep;
76:102830.
PMID: 39318788
Background: Cardiac surgery invariably triggers acute kidney stress causing adverse renal outcomes. The AKITA study evaluated the efficacy and safety of RMC-035, a novel analogue of alpha-1-microglobulin, for reducing cardiac...
4.
Burmakin M, Gilmour P, Gram M, Shushakova N, Sandoval R, Molitoris B, et al.
Am J Physiol Renal Physiol
. 2024 May;
327(1):F103-F112.
PMID: 38779750
α-1-Microglobulin (A1M) is a circulating glycoprotein with antioxidant, heme-binding, and mitochondrial protection properties. The investigational drug RMC-035, a modified therapeutic A1M protein, was assessed for biodistribution and pharmacological activity in...
5.
Mazer C, Siadati-Fini N, Boehm J, Wirth F, Myjavec A, Brown C, et al.
BMJ Open
. 2023 Apr;
13(4):e068363.
PMID: 37024249
Introduction: Acute kidney injury (AKI) is a common complication after cardiac surgery (CS) and is associated with adverse short-term and long-term outcomes. Alpha-1-microglobulin (A1M) is a circulating glycoprotein with antioxidant,...
6.
Rubinstein T, Reuveni I, Hesin A, Klein-Goldberg A, Olauson H, Larsson T, et al.
Cancers (Basel)
. 2021 Dec;
13(24).
PMID: 34944918
Klotho is an anti-aging transmembrane protein, which can be shed and can function as a hormone. Accumulating data indicate that klotho is a tumor suppressor in a wide array of...
7.
Alderson H, Chinnadurai R, Ibrahim S, Asar O, Ritchie J, Middleton R, et al.
BMC Nephrol
. 2021 Oct;
22(1):329.
PMID: 34600515
Background: Fibroblast growth factor23 (FGF23) is elevated in CKD and has been associated with outcomes such as death, cardiovascular (CV) events and progression to Renal Replacement therapy (RRT). The majority...
8.
Snelder N, Hoefman S, Garcia-Hernandez A, Onkels H, Larsson T, Bergmann K
J Pharmacokinet Pharmacodyn
. 2020 Sep;
48(1):39-53.
PMID: 32930923
ASP8232 is a novel inhibitor of vascular adhesion protein-1 that was under evaluation for reducing residual albuminuria in patients with diabetic kidney disease. To characterize the pharmacokinetics (PK) of ASP8232...
9.
Hoefman S, Snelder N, van Noort M, Garcia-Hernandez A, Onkels H, Larsson T, et al.
J Pharmacokinet Pharmacodyn
. 2020 Sep;
48(1):21-38.
PMID: 32929612
The vascular adhesion protein-1 (VAP-1) inhibitor ASP8232 reduces albuminuria in patients with type 2 diabetes and chronic kidney disease. A mechanism-based model was developed to quantify the effects of ASP8232...
10.
Zhou B, Gao M, Feng X, Huang L, Huang Q, Kootala S, et al.
Carbohydr Polym
. 2020 Jan;
232:115802.
PMID: 31952601
A series of biocompatible and non- toxic polysaccharide molecules have been successfully fabricated and explored their potential application for scavenging the carbonyl species in vitro. These macromolecules were dextrans with...