Tinne Verhulst
Overview
Explore the profile of Tinne Verhulst including associated specialties, affiliations and a list of published articles.
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Articles
5
Citations
209
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0
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Recent Articles
1.
Mammoliti O, Carbajo R, Perez-Benito L, Yu X, Prieri M, Bontempi L, et al.
J Med Chem
. 2025 Feb;
68(4):4848-4887.
PMID: 39932543
NLRP3 is a danger sensor protein responsible for inflammasome activation. This leads to pro-inflammatory cytokines release, like IL-1β, and pyroptosis, a regulated cell death. Mounting evidence associates excessive NLRP3 activation...
2.
Kwon M, Thuring J, Querolle O, Dai X, Verhulst T, Pande V, et al.
Blood
. 2024 Jun;
144(11):1206-1220.
PMID: 38905635
The interaction between menin and histone-lysine N-methyltransferase 2A (KMT2A) is a critical dependency for KMT2A- or nucleophosmin 1 (NPM1)-altered leukemias and an emerging opportunity for therapeutic development. JNJ-75276617 (bleximenib) is...
3.
Brehmer D, Beke L, Wu T, Millar H, Moy C, Sun W, et al.
Mol Cancer Ther
. 2021 Sep;
20(12):2317-2328.
PMID: 34583982
The protein arginine methyltransferase 5 (PRMT5) methylates a variety of proteins involved in splicing, multiple signal transduction pathways, epigenetic control of gene expression, and mechanisms leading to protein expression required...
4.
Perera T, Jovcheva E, Mevellec L, Vialard J, De Lange D, Verhulst T, et al.
Mol Cancer Ther
. 2017 Mar;
16(6):1010-1020.
PMID: 28341788
Fibroblast growth factor (FGF) signaling plays critical roles in key biological processes ranging from embryogenesis to wound healing and has strong links to several hallmarks of cancer. Genetic alterations in...
5.
Casneuf T, Axel A, King P, Alvarez J, Werbeck J, Verhulst T, et al.
Breast Cancer (Dove Med Press)
. 2016 Feb;
8:13-27.
PMID: 26893580
Introduction: Interleukin-6 (IL-6) is an important growth factor for estrogen receptor-α (ERα)-positive breast cancer, and elevated serum IL-6 is associated with poor prognosis. Methods: The role of the phosphorylated signal...
6.
De Schepper S, Bruwiere H, Verhulst T, Steller U, Andries L, Wouters W, et al.
J Pharmacol Exp Ther
. 2003 Jan;
304(2):881-8.
PMID: 12538846
The naturally occurring cyclic tetrapeptide chlamydocin is a very potent inhibitor of cell proliferation. Here we show that chlamydocin is a highly potent histone deacetylase (HDAC) inhibitor, inhibiting HDAC activity...