Timothy Chai
Overview
Explore the profile of Timothy Chai including associated specialties, affiliations and a list of published articles.
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Articles
12
Citations
181
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Recent Articles
1.
Chai T, Loh K, Weissman I
bioRxiv
. 2024 Oct;
PMID: 39386445
T cell-targeted therapies are commonly used to manage T cell hyperactivity in autoimmune disorders, graft-versus-host diseases (GVHD), and transplant rejections. However, many patients experience significant side effects or inadequate responses...
2.
Fowler J, Zheng S, Nguyen A, Chen A, Xiong X, Chai T, et al.
Dev Cell
. 2024 Apr;
59(9):1110-1131.e22.
PMID: 38569552
The developmental origin of blood-forming hematopoietic stem cells (HSCs) is a longstanding question. Here, our non-invasive genetic lineage tracing in mouse embryos pinpoints that artery endothelial cells generate HSCs. Arteries...
3.
Liu S, Chai T, Garcia-Marques F, Yin Q, Hsu E, Shen M, et al.
Cell Rep Med
. 2024 Jan;
5(2):101381.
PMID: 38244540
Neuroendocrine carcinomas, such as neuroendocrine prostate cancer and small-cell lung cancer, commonly have a poor prognosis and limited therapeutic options. We report that ubiquitin carboxy-terminal hydrolase L1 (UCHL1), a deubiquitinating...
4.
Ang L, Nguyen A, Liu K, Chen A, Xiong X, Curtis M, et al.
Cell
. 2022 Jun;
185(14):2523-2541.e30.
PMID: 35738284
Stem cell research endeavors to generate specific subtypes of classically defined "cell types." Here, we generate >90% pure human artery or vein endothelial cells from pluripotent stem cells within 3-4 ...
5.
Raftrey B, Williams I, Rios Coronado P, Fan X, Chang A, Zhao M, et al.
Circ Res
. 2021 Aug;
129(7):702-716.
PMID: 34383559
[Figure: see text].
6.
Evans C, Olson J, Mondal B, Kandimalla P, Abbasi A, Abdusamad M, et al.
G3 (Bethesda)
. 2021 Feb;
11(1).
PMID: 33561251
Undergraduate students participating in the UCLA Undergraduate Research Consortium for Functional Genomics (URCFG) have conducted a two-phased screen using RNA interference (RNAi) in combination with fluorescent reporter proteins to identify...
7.
Faltermeier C, Chai T, Syed S, Lau N, Elkaim L, Ibrahim G, et al.
PLoS One
. 2019 Oct;
14(10):e0224570.
PMID: 31648260
[This corrects the article DOI: 10.1371/journal.pone.0223051.].
8.
Faltermeier C, Chai T, Syed S, Lau N, Elkaim L, Ibrahim G, et al.
PLoS One
. 2019 Sep;
14(9):e0223051.
PMID: 31553771
Introduction: Brain tumors are the most common solid malignancy and leading cause of cancer-related deaths in infants. Current epidemiological data is limited by low numbers of reported cases. This study...
9.
Lee J, Bangayan N, Chai T, Smith B, Pariva T, Yun S, et al.
Proc Natl Acad Sci U S A
. 2018 Apr;
115(19):E4473-E4482.
PMID: 29686080
Prostate cancer is a heterogeneous disease composed of divergent molecular and histologic subtypes, including prostate adenocarcinoma (PrAd) and neuroendocrine prostate cancer (NEPC). While PrAd is the major histology in prostate...
10.
Evdokimov N, Clark P, Flores G, Chai T, Faull K, Phelps M, et al.
J Med Chem
. 2015 Jun;
58(14):5538-47.
PMID: 26102222
Life-threatening acute liver failure can be triggered by a variety of factors, including common drugs such as acetaminophen. Positron emission tomography (PET) is rarely used to monitor liver function, in...