Timothy A Thornton
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Explore the profile of Timothy A Thornton including associated specialties, affiliations and a list of published articles.
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90
Citations
4328
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Recent Articles
1.
Grinde K, Browning B, Reiner A, Thornton T, Browning S
PLoS Genet
. 2024 Dec;
20(12):e1011242.
PMID: 39680601
Principal component analysis (PCA) is widely used to control for population structure in genome-wide association studies (GWAS). Top principal components (PCs) typically reflect population structure, but challenges arise in deciding...
2.
Gaynor S, Joseph T, Bai X, Zou Y, Boutkov B, Maxwell E, et al.
Nat Genet
. 2024 Sep;
56(11):2345-2351.
PMID: 39322778
Whole-genome sequencing (WGS), whole-exome sequencing (WES) and array genotyping with imputation (IMP) are common strategies for assessing genetic variation and its association with medically relevant phenotypes. To date, there has...
3.
Horimoto A, Sun Q, Lash J, Daviglus M, Cai J, Haack K, et al.
Circ Genom Precis Med
. 2024 Jul;
17(4):e004314.
PMID: 38950085
Background: Chronic kidney disease (CKD) is highly prevalent in Central America, and genetic factors may contribute to CKD risk. To understand the influences of genetic admixture on CKD susceptibility, we...
4.
Grinde K, Browning B, Reiner A, Thornton T, Browning S
bioRxiv
. 2024 Apr;
PMID: 38617337
Principal component analysis (PCA) is widely used to control for population structure in genome-wide association studies (GWAS). Top principal components (PCs) typically reflect population structure, but challenges arise in deciding...
5.
Ziyatdinov A, Torres J, Alegre-Diaz J, Backman J, Mbatchou J, Turner M, et al.
Nature
. 2024 Feb;
626(8001):E18.
PMID: 38332034
No abstract available.
6.
Sun Q, Rowland B, Chen J, Mikhaylova A, Avery C, Peters U, et al.
Nat Commun
. 2024 Feb;
15(1):1016.
PMID: 38310129
Polygenic risk scores (PRS) have shown successes in clinics, but most PRS methods focus only on participants with distinct primary continental ancestry without accommodating recently-admixed individuals with mosaic continental ancestry...
7.
Ziyatdinov A, Torres J, Alegre-Diaz J, Backman J, Mbatchou J, Turner M, et al.
Nature
. 2023 Oct;
622(7984):784-793.
PMID: 37821707
The Mexico City Prospective Study is a prospective cohort of more than 150,000 adults recruited two decades ago from the urban districts of Coyoacán and Iztapalapa in Mexico City. Here...
8.
Leal T, Rao S, French-Kwawu J, Gouveia M, Borda V, Bandres-Ciga S, et al.
Mov Disord
. 2023 Jul;
38(9):1625-1635.
PMID: 37469269
Background: Sex differences in Parkinson's disease (PD) risk are well-known. However, the role of sex chromosomes in the development and progression of PD is still unclear. Objective: The objective of...
9.
Horimoto A, Boyken L, Blue E, Grinde K, Nafikov R, Sohi H, et al.
HGG Adv
. 2023 Jun;
4(3):100207.
PMID: 37333771
Alzheimer disease (AD) is the most common form of senile dementia, with high incidence late in life in many populations including Caribbean Hispanic (CH) populations. Such admixed populations, descended from...
10.
Guen Y, Raulin A, Logue M, Sherva R, Belloy M, Eger S, et al.
JAMA
. 2023 Feb;
329(7):551-560.
PMID: 36809323
Importance: Numerous studies have established the association of the common APOE ε2 and APOE ε4 alleles with Alzheimer disease (AD) risk across ancestries. Studies of the interaction of these alleles...