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Timothee Fettrelet

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Citations 185
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1.
Fettrelet T, Hosseini A, Wyss J, Boros-Majewska J, Stojkov D, Yousefi S, et al.
Cells . 2024 Dec; 13(23). PMID: 39682685
Eosinophils, a type of granulocyte derived from myeloid precursors in the bone marrow, are distinguished by their cytoplasmic granules. They play crucial roles in immunoregulation, tissue homeostasis, and host defense,...
2.
Gigon L, Fettrelet T, Miholic M, McLeish K, Yousefi S, Stojkov D, et al.
Front Immunol . 2023 Oct; 14:1272699. PMID: 37885878
Neutrophils are a specialized subset of white blood cells, which have the ability to store pre-formed mediators in their cytoplasmic granules. Neutrophils are well-known effector cells involved in host protection...
3.
Gigon L, Fettrelet T, Yousefi S, Simon D, Simon H
Allergy . 2023 Apr; 78(7):1810-1846. PMID: 37102676
Eosinophils are bone marrow-derived granulocytes and are found in low numbers in the peripheral blood of healthy subjects. In type 2 inflammatory diseases, eosinopoiesis in the bone marrow is increased,...
4.
Hosseini A, Stojkov D, Fettrelet T, Bilyy R, Yousefi S, Simon H
Int J Mol Sci . 2023 Feb; 24(3). PMID: 36768969
Neutrophil extracellular traps (NETs) and oxidative stress are considered to be beneficial in the innate immune defense against pathogens. However, defective clearance of NETs in the lung of acute respiratory...
5.
Bjanes E, Sillas R, Matsuda R, Demarco B, Fettrelet T, DeLaney A, et al.
PLoS Pathog . 2021 Oct; 17(10):e1009967. PMID: 34648590
Cell death plays a critical role in inflammatory responses. During pyroptosis, inflammatory caspases cleave Gasdermin D (GSDMD) to release an N-terminal fragment that generates plasma membrane pores that mediate cell...
6.
Fettrelet T, Gigon L, Karaulov A, Yousefi S, Simon H
Int J Mol Sci . 2021 Jul; 22(13). PMID: 34209362
Eosinophils are specialized white blood cells, which are involved in the pathology of diverse allergic and nonallergic inflammatory diseases. Eosinophils are traditionally known as cytotoxic effector cells but have been...
7.
Germic N, Fettrelet T, Stojkov D, Hosseini A, Horn M, Karaulov A, et al.
Cells . 2021 Feb; 10(2). PMID: 33546138
Eosinophils are a subset of granulocytes characterized by a high abundance of specific granules in their cytoplasm. To act as effector cells, eosinophils degranulate and form eosinophil extracellular traps (EETs),...
8.
Demarco B, Grayczyk J, Bjanes E, Le Roy D, Tonnus W, Assenmacher C, et al.
Sci Adv . 2020 Nov; 6(47). PMID: 33208362
Gasdermin D (GSDMD) is a pore-forming protein that promotes pyroptosis and release of proinflammatory cytokines. Recent studies revealed that apoptotic caspase-8 directly cleaves GSDMD to trigger pyroptosis. However, the molecular...