Tim Sparwasser
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Explore the profile of Tim Sparwasser including associated specialties, affiliations and a list of published articles.
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205
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11770
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Recent Articles
1.
Goranovic D, Jenko B, Ramsak B, Podgorsek Berke A, Bedrac L, Horvat J, et al.
J Nat Prod
. 2025 Mar;
PMID: 40062573
The medically important immunosuppressant FK506 is a structurally complex macrolactone biosynthesized by a combined polyketide synthase and a nonribosomal peptide synthetase enzyme complex. Its acyltransferase domain 4 (AT4) selects an...
2.
Stuve P, Godoy G, Ferreyra F, Hellriegel F, Boukhallouk F, Kao Y, et al.
Mol Metab
. 2025 Feb;
94:102111.
PMID: 39929287
Objective: Regulatory T cells (Tregs) are essential in maintaining immune tolerance and controlling inflammation. Treg stability relies on transcriptional and post-translational mechanisms, including histone acetylation at the Foxp3 locus and...
3.
Zhou Y, Wang X, Yin W, Li Y, Guo Y, Chen C, et al.
CNS Neurosci Ther
. 2024 Jul;
30(7):e14747.
PMID: 38973085
Aim: To explore the regulatory mechanisms of microglia-mediated cytotoxic CD8 T-cell infiltration in the white matter injury of perioperative stroke (PIS). Methods: Adult male C57BL/6 mice were subjected to ileocolic...
4.
Almeida L, Dhillon-LaBrooy A, Sparwasser T
Trends Endocrinol Metab
. 2023 Dec;
35(3):235-248.
PMID: 38040578
The function and phenotype of macrophages are intimately linked with pathogen detection. On sensing pathogen-derived signals and molecules, macrophages undergo a carefully orchestrated process of polarization to acquire pathogen-clearing properties....
5.
Venken K, Decruy T, Sparwasser T, Elewaut D
Immunology
. 2023 Nov;
171(2):277-285.
PMID: 37984469
Immunomodulatory T cells play a pivotal role in protection against (auto)immune-mediated diseases that open perspectives for therapeutic modulation. However, how immune regulatory networks operate in vivo is less understood. To...
6.
Dhillon-LaBrooy A, Braband K, Tantawy E, Rampoldi F, Kao Y, Boukhallouk F, et al.
J Invest Dermatol
. 2023 Oct;
144(4):844-854.e2.
PMID: 37832844
Psoriasis is an inflammatory skin disorder that is characterized by keratinocyte hyperproliferation in response to immune cell infiltration and cytokine secretion in the dermis. γδ T cells expressing the Vγ4...
7.
Damasceno L, Cunha T, Cunha F, Sparwasser T, Alves-Filho J
Int Immunopharmacol
. 2023 Oct;
124(Pt B):111007.
PMID: 37778170
The STING signaling pathway has gained attention over the last few years due to its ability to incite antimicrobial and antitumoral immunity. Conversely, in mouse models of autoimmunity such as...
8.
Kao Y, Mamareli P, Dhillon-LaBrooy A, Stuve P, Godoy G, Velasquez L, et al.
J Mol Med (Berl)
. 2023 Aug;
101(9):1153-1166.
PMID: 37594540
Psoriasis is a chronic inflammatory skin disease driven by the IL-23/IL-17 axis. It results from excessive activation of effector T cells, including T helper (Th) and cytotoxic T (Tc) cells,...
9.
Venken K, Jarlborg M, Decruy T, Mortier C, Vlieghe C, Gilis E, et al.
Ann Rheum Dis
. 2023 May;
82(8):1076-1090.
PMID: 37197892
Objectives: Gut and joint inflammation commonly co-occur in spondyloarthritis (SpA) which strongly restricts therapeutic modalities. The immunobiology underlying differences between gut and joint immune regulation, however, is poorly understood. We...
10.
Tenaglia A, Lujan L, Rios D, Molina C, Midlej V, Iribarren P, et al.
Nat Commun
. 2023 May;
14(1):2537.
PMID: 37137944
The genomes of most protozoa encode families of variant surface antigens. In some parasitic microorganisms, it has been demonstrated that mutually exclusive changes in the expression of these antigens allow...