» Authors » Tim H M Huang

Tim H M Huang

Explore the profile of Tim H M Huang including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 28
Citations 672
Followers 0
Related Specialties
Top 10 Co-Authors
Published In
Affiliations
Soon will be listed here.
Recent Articles
11.
Gu F, Doderer M, Huang Y, Roa J, Goodfellow P, Kizer E, et al.
PLoS One . 2013 May; 8(4):e60980. PMID: 23630576
Background: DNA methylation of promoter CpG islands is associated with gene suppression, and its unique genome-wide profiles have been linked to tumor progression. Coupled with high-throughput sequencing technologies, it can...
12.
Wu H, Zheng P, Jiang G, Liu Y, Nephew K, Huang T, et al.
BMC Genomics . 2012 Nov; 13 Suppl 6:S6. PMID: 23134758
Background: Estrogens control multiple functions of hormone-responsive breast cancer cells. They regulate diverse physiological processes in various tissues through genomic and non-genomic mechanisms that result in activation or repression of...
13.
Villar D, Ortiz-Barahona A, Gomez-Maldonado L, Pescador N, Sanchez-Cabo F, Hackl H, et al.
PLoS One . 2012 Oct; 7(9):e45708. PMID: 23029193
The transcriptional response driven by Hypoxia-inducible factor (HIF) is central to the adaptation to oxygen restriction. Despite recent characterization of genome-wide HIF DNA binding locations and hypoxia-regulated transcripts in different...
14.
Teng M, Wang Y, Kim S, Li L, Shen C, Wang G, et al.
Comp Funct Genomics . 2012 Sep; 2012:376706. PMID: 22956892
A number of empirical Bayes models (each with different statistical distribution assumptions) have now been developed to analyze differential DNA methylation using high-density oligonucleotide tiling arrays. However, it remains unclear...
15.
Teng M, Balch C, Liu Y, Li M, Huang T, Wang Y, et al.
PLoS One . 2012 Mar; 7(3):e32928. PMID: 22412954
It is now established that, as compared to normal cells, the cancer cell genome has an overall inverse distribution of DNA methylation ("methylome"), i.e., predominant hypomethylation and localized hypermethylation, within...
16.
Sun S, Chen Z, Yan P, Huang Y, Huang T, Lin S
BMC Bioinformatics . 2011 Feb; 12:54. PMID: 21324121
Background: DNA methylation has been shown to play an important role in the silencing of tumor suppressor genes in various tumor types. In order to have a system-wide understanding of...
17.
Lin Y, Shaw A, Wang S, Hsu C, Teng I, Tseng M, et al.
J Biomed Sci . 2011 Jan; 18:3. PMID: 21219604
Background: Targeting abnormal DNA methylation represents a therapeutically relevant strategy for cancer treatment as demonstrated by the US Food and Drug Administration approval of the DNA methyltransferase inhibitors azacytidine and...
18.
Wang G, Wang Y, Shen C, Huang Y, Huang K, Huang T, et al.
PLoS One . 2010 Nov; 5(11):e13798. PMID: 21072189
MicroRNAs are small non-coding RNAs involved in post-transcriptional regulation of gene expression. Due to the poor annotation of primary microRNA (pri-microRNA) transcripts, the precise location of promoter regions driving expression...
19.
Bapat S, Jin V, Berry N, Balch C, Sharma N, Kurrey N, et al.
Epigenetics . 2010 Aug; 5(8):716-29. PMID: 20676026
"Epigenetic plasticity" refers to the capability of mammalian cells to alter their differentiation status via chromatin remodeling-associated alterations in gene expression. While epigenetic plasticity has been best associated with lineage...
20.
Sun S, Yan P, Huang T, Lin S
BMC Bioinformatics . 2009 Dec; 10:404. PMID: 20003206
Background: DNA methylation plays an important role in the process of tumorigenesis. Identifying differentially methylated genes or CpG islands (CGIs) associated with genes between two tumor subtypes is thus an...