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Tilman E Schaffer

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Articles 73
Citations 1165
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Recent Articles
1.
Budbazar E, Balmes A, Elliott D, Tintin L, Kopp T, Feil S, et al.
bioRxiv . 2025 Mar; PMID: 40027660
Objective: Arterial stiffness, or loss of elastic compliance in large arteries, is an independent precursor of cardiovascular disease (CVD) and dementia . Akin to anti-hypertensive and lipid-lowering drugs, arterial de-stiffening...
2.
von Eysmondt H, Seifert J, Rheinlaender J, Schaffer T
Acta Biomater . 2025 Feb; PMID: 39986637
Platelets have long been established as a safeguard of our vascular system. Recently, haptotactic platelet migration has been discovered as a part of the immune response. In addition, platelets exhibit...
3.
Hundsdorfer L, Muenkel M, Aparicio-Yuste R, Sanchez-Rendon J, Gomez-Benito M, Balmes A, et al.
Cell Rep . 2025 Jan; 44(1):115193. PMID: 39817903
Epithelial cells respond to infection with the intracellular bacterial pathogen Listeria monocytogenes by altering their mechanics to promote collective infected cell extrusion (CICE) and limit infection spread across cell monolayers....
4.
Schaale D, Laspa Z, Balmes A, Sigle M, Dicenta-Baunach V, Hochuli R, et al.
FASEB J . 2024 Nov; 38(21):e70155. PMID: 39530531
Platelet activation plays a critical role in thrombosis and hemostasis. Several pathophysiological situations lead to hemolysis, resulting in the liberation of free ferric iron-containing hemin. Hemin has been shown to...
5.
Cain D, Cao E, Vlassiouk I, Schaffer T, Siwy Z
Faraday Discuss . 2024 Oct; 257:344-359. PMID: 39440602
There has been a great amount of interest in nanopores as the basis for sensors and templates for preparation of biomimetic channels as well as model systems to understand transport...
6.
Sigle M, Rohlfing A, Cruz Santos M, Kopp T, Krutzke K, Gidlund V, et al.
Circ Res . 2024 Aug; 135(7):758-773. PMID: 39140165
Background: Cardiac hypertrophy is characterized by remodeling of the myocardium, which involves alterations in the ECM (extracellular matrix) and cardiomyocyte structure. These alterations critically contribute to impaired contractility and relaxation,...
7.
Krutzke K, Seifert J, Gawaz M, Rheinlaender J, Schaffer T
Thromb Haemost . 2024 Aug; PMID: 39094791
Background:  Platelets are anucleate cells that play an important role in wound closure following vessel injury. Maintaining a constant platelet volume is critical for platelet function. For example, water-induced swelling...
8.
Rheinlaender J, Schaffer T
ACS Nano . 2024 Jun; 18(25):16257-16264. PMID: 38868865
Imaging and probing liquid-liquid interfaces at the micro- and nanoscale are of high relevance, for example, in materials science, surface chemistry, and microfluidics. However, existing imaging techniques are limited in...
9.
Raja Xavier J, Rianna C, Hellwich E, Nikolou I, Lankapalli A, Brucker S, et al.
Commun Biol . 2024 May; 7(1):530. PMID: 38704457
Cell stiffness is regulated by dynamic interaction between ras-related C3 botulinum toxin substrate 1 (Rac1) and p21 protein-activated kinase 1 (PAK1) proteins, besides other biochemical and molecular regulators. In this...
10.
Balmes A, Rodriguez J, Seifert J, Pinto-Quintero D, Khawaja A, Boffito M, et al.
Platelets . 2024 Feb; 35(1):2313359. PMID: 38353233
Cyclic guanosine monophosphate (cGMP) is a second messenger produced by the NO-sensitive guanylyl cyclase (NO-GC). The NO-GC/cGMP pathway in platelets has been extensively studied. However, its role in regulating the...