Tiffany C Hadzi
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Explore the profile of Tiffany C Hadzi including associated specialties, affiliations and a list of published articles.
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11
Citations
487
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Recent Articles
1.
Latourelle J, Beste M, Hadzi T, Miller R, Oppenheim J, Valko M, et al.
Lancet Neurol
. 2017 Sep;
16(11):908-916.
PMID: 28958801
Background: Better understanding and prediction of progression of Parkinson's disease could improve disease management and clinical trial design. We aimed to use longitudinal clinical, molecular, and genetic data to develop...
2.
Nagle M, Latourelle J, Labadorf A, Dumitriu A, Hadzi T, Beach T, et al.
PLoS One
. 2016 Aug;
11(8):e0160925.
PMID: 27508417
Genome-wide association studies (GWAS) have identified the GAK/DGKQ/IDUA region on 4p16.3 among the top three risk loci for Parkinson's disease (PD), but the specific gene and risk mechanism are unclear....
3.
Labadorf A, Hoss A, Lagomarsino V, Latourelle J, Hadzi T, Bregu J, et al.
PLoS One
. 2016 Jul;
11(7):e0160295.
PMID: 27454300
[This corrects the article DOI: 10.1371/journal.pone.0143563.].
4.
Labadorf A, Hoss A, Lagomarsino V, Latourelle J, Hadzi T, Bregu J, et al.
PLoS One
. 2015 Dec;
10(12):e0143563.
PMID: 26636579
Huntington's Disease (HD) is a devastating neurodegenerative disorder that is caused by an expanded CAG trinucleotide repeat in the Huntingtin (HTT) gene. Transcriptional dysregulation in the human HD brain has...
5.
Hoss A, Lagomarsino V, Frank S, Hadzi T, Myers R, Latourelle J
Mov Disord
. 2015 Nov;
30(14):1961-4.
PMID: 26573701
Background: Biomarkers for Huntington's disease progression could accelerate therapeutic developments and improve patient care. Brain microRNAs relating to clinical features of Huntington's disease may represent a potential Huntington's disease biomarker...
6.
Hoss A, Labadorf A, Latourelle J, Kartha V, Hadzi T, Gusella J, et al.
BMC Med Genomics
. 2015 Apr;
8:10.
PMID: 25889241
Background: MicroRNAs (miRNAs) are small non-coding RNAs that recognize sites of complementarity of target messenger RNAs, resulting in transcriptional regulation and translational repression of target genes. In Huntington's disease (HD),...
7.
Hoss A, Kartha V, Dong X, Latourelle J, Dumitriu A, Hadzi T, et al.
PLoS Genet
. 2014 Mar;
10(2):e1004188.
PMID: 24586208
Transcriptional dysregulation has long been recognized as central to the pathogenesis of Huntington's disease (HD). MicroRNAs (miRNAs) represent a major system of post-transcriptional regulation, by either preventing translational initiation or...
8.
Latourelle J, Dumitriu A, Hadzi T, Beach T, Myers R
PLoS One
. 2012 Oct;
7(10):e46199.
PMID: 23071545
The recent Parkinson Disease GWAS Consortium meta-analysis and replication study reports association at several previously confirmed risk loci SNCA, MAPT, GAK/DGKQ, and HLA and identified a novel risk locus at...
9.
Hadzi T, Hendricks A, Latourelle J, Lunetta K, Cupples L, Gillis T, et al.
Neurology
. 2012 Oct;
79(16):1708-15.
PMID: 23035064
Objective: To evaluate the relationship of striatal involvement in Huntington disease (HD) to involvement in other brain regions, CAG repeat size, onset age, and other factors. Methods: We examined patterns...
10.
Dumitriu A, Latourelle J, Hadzi T, Pankratz N, Garza D, Miller J, et al.
PLoS Genet
. 2012 Jul;
8(6):e1002794.
PMID: 22761592
Parkinson disease (PD) is a complex neurodegenerative disorder with largely unknown genetic mechanisms. While the degeneration of dopaminergic neurons in PD mainly takes place in the substantia nigra pars compacta...