Tiffany Amariuta
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Explore the profile of Tiffany Amariuta including associated specialties, affiliations and a list of published articles.
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27
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979
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Recent Articles
1.
Xu Z, Massarat A, Rumker L, Gymrek M, Raychaudhuri S, Zhou W, et al.
bioRxiv
. 2025 Mar;
PMID: 40060452
For gene expression traits, -genetic heritability can quantify the strength of genetic regulation in particular cell types, elucidating the cell-type-specificity of disease variants and genes. To estimate gene expression heritability,...
2.
Strober B, Zhang M, Amariuta T, Rossen J, Price A
Nat Genet
. 2025 Jan;
57(1):42-52.
PMID: 39747598
Complex diseases often have distinct mechanisms spanning multiple tissues. We propose tissue-gene fine-mapping (TGFM), which infers the posterior inclusion probability (PIP) for each gene-tissue pair to mediate a disease locus...
3.
Luo Y, Huang C, Howard N, Wang X, Liu Q, Li X, et al.
Nat Commun
. 2024 Nov;
15(1):10393.
PMID: 39613754
Infectious disease is the result of interactions between host and pathogen and can depend on genetic variations in both. We conduct a genome-to-genome study of paired human and Mycobacterium tuberculosis...
4.
Akamatsu K, Golzari S, Amariuta T
medRxiv
. 2024 Oct;
PMID: 39399015
While disease-associated variants identified by genome-wide association studies (GWAS) most likely regulate gene expression levels, linking variants to target genes is critical to determining the functional mechanisms of these variants....
5.
DeForest N, Wang Y, Zhu Z, Dron J, Koesterer R, Natarajan P, et al.
Nat Commun
. 2024 Sep;
15(1):8068.
PMID: 39277575
Insulin resistance causes multiple epidemic metabolic diseases, including type 2 diabetes, cardiovascular disease, and fatty liver, but is not routinely measured in epidemiological studies. To discover novel insulin resistance genes...
6.
Ishikawa Y, Tanaka N, Asano Y, Kodera M, Shirai Y, Akahoshi M, et al.
Nat Commun
. 2024 Jan;
15(1):319.
PMID: 38296975
Here we report the largest Asian genome-wide association study (GWAS) for systemic sclerosis performed to date, based on data from Japanese subjects and comprising of 1428 cases and 112,599 controls....
7.
Tegtmeyer M, Arora J, Asgari S, Cimini B, Nadig A, Peirent E, et al.
Nat Commun
. 2024 Jan;
15(1):347.
PMID: 38184653
The morphology of cells is dynamic and mediated by genetic and environmental factors. Characterizing how genetic variation impacts cell morphology can provide an important link between disease association and cellular...
8.
Gupta A, Weinand K, Nathan A, Sakaue S, Zhang M, Donlin L, et al.
Nat Genet
. 2023 Nov;
55(12):2200-2210.
PMID: 38036783
In autoimmune diseases such as rheumatoid arthritis, the immune system attacks the body's own cells. Developing a precise understanding of the cell states where noncoding autoimmune risk variants impart causal...
9.
Strober B, Zhang M, Amariuta T, Rossen J, Price A
medRxiv
. 2023 Nov;
PMID: 37961337
Heritable diseases often manifest in a highly tissue-specific manner, with different disease loci mediated by genes in distinct tissues or cell types. We propose Tissue-Gene Fine-Mapping (TGFM), a fine-mapping method...
10.