Tiago D Serafim
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Explore the profile of Tiago D Serafim including associated specialties, affiliations and a list of published articles.
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19
Citations
468
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Recent Articles
1.
Cecilio P, Iniguez E, Huffcutt P, Ribeiro S, Kamhawi S, Valenzuela J, et al.
Trends Parasitol
. 2025 Feb;
41(3):196-209.
PMID: 39979193
The impact of blood and its factors on vector-borne diseases is significant and multifaceted yet understudied. While blood is expected to play a central role in transmission, pathogen development, vector...
2.
Serafim T, Iniguez E, Barletta A, Cecilio P, Doehl J, Short M, et al.
Nature
. 2023 Oct;
623(7985):149-156.
PMID: 37880367
Host factors that mediate Leishmania genetic exchange are not well defined. Here we demonstrate that natural IgM (IgMn) antibodies mediate parasite genetic exchange by inducing the transient formation of a...
3.
Iniguez E, Saha S, Petrellis G, Menenses C, Herbert S, Gonzalez-Rangel Y, et al.
J Infect Dis
. 2022 Sep;
226(10):1842-1851.
PMID: 36052609
Incidence of visceral leishmaniasis (VL) in the Indian subcontinent (ISC) has declined by more than 95% since initiation of the elimination program in 2005. As the ISC transitions to the...
4.
Serafim T, Coutinho-Abreu I, Dey R, Kissinger R, Valenzuela J, Oliveira F, et al.
Trends Parasitol
. 2021 Aug;
37(11):976-987.
PMID: 34389215
The contribution of vector transmission to pathogen establishment is largely underrated. For Leishmania, transmission by sand flies is critical to early survival involving an irreproducible myriad of parasite, vector, and...
5.
Guimaraes-Costa A, Shannon J, Waclawiak I, Oliveira J, Meneses C, de Castro W, et al.
Nat Commun
. 2021 May;
12(1):3213.
PMID: 34050141
Apart from bacterial formyl peptides or viral chemokine mimicry, a non-vertebrate or insect protein that directly attracts mammalian innate cells such as neutrophils has not been molecularly characterized. Here, we...
6.
Garlapati R, Iniguez E, Serafim T, Mishra P, Rooj B, Sinha B, et al.
Front Cell Infect Microbiol
. 2021 Mar;
11:641632.
PMID: 33768013
Visceral leishmaniasis (VL) is a potentially deadly parasitic disease. In the Indian sub-continent, VL is caused by and transmitted the bite of an infected female sand fly, the only competent...
7.
Cecilio P, Oristian J, Meneses C, Serafim T, Valenzuela J, Cordeiro da Silva A, et al.
Sci Rep
. 2020 Oct;
10(1):18653.
PMID: 33122717
Leishmaniasis is a spectrum of diseases transmitted by sand fly vectors that deposit Leishmania spp. parasites in the host skin during blood feeding. Currently, available treatment options are limited, associated...
8.
DeSouza-Vieira T, Iniguez E, Serafim T, de Castro W, Karmakar S, Disotuar M, et al.
Cell Rep
. 2020 Oct;
33(4):108317.
PMID: 33113362
Hematophagous vectors lacerate host skin and capillaries to acquire a blood meal, resulting in leakage of red blood cells (RBCs) and inflammation. Here, we show that heme oxygenase-1 (HO-1), a...
9.
Zhang W, Karmakar S, Gannavaram S, Dey R, Lypaczewski P, Ismail N, et al.
Nat Commun
. 2020 Jul;
11(1):3461.
PMID: 32651371
Leishmaniasis is a neglected tropical disease caused by Leishmania protozoa transmitted by infected sand flies. Vaccination through leishmanization with live Leishmania major has been used successfully but is no longer...
10.
Kamhawi S, Serafim T
Trends Parasitol
. 2020 May;
36(6):498-501.
PMID: 32359871
Epigenetic manipulation of host cells by intracellular pathogens has become increasingly evident. Lecoeur et al. show us how Leishmania amazonensis inhibits macrophage inflammasomes by modifying histone H3 activation marks on...