Thorsten Luhrs
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Explore the profile of Thorsten Luhrs including associated specialties, affiliations and a list of published articles.
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Articles
18
Citations
1464
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0
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Recent Articles
1.
He L, Bardiaux B, Ahmed M, Spehr J, Konig R, Lunsdorf H, et al.
Proc Natl Acad Sci U S A
. 2016 Jan;
113(3):E272-81.
PMID: 26733681
The controlled formation of filamentous protein complexes plays a crucial role in many biological systems and represents an emerging paradigm in signal transduction. The mitochondrial antiviral signaling protein (MAVS) is...
2.
Hellert J, Weidner-Glunde M, Krausze J, Lunsdorf H, Ritter C, Schulz T, et al.
Proc Natl Acad Sci U S A
. 2015 May;
112(21):6694-9.
PMID: 25947153
Kaposi sarcoma herpesvirus (KSHV) persists as a latent nuclear episome in dividing host cells. This episome is tethered to host chromatin to ensure proper segregation during mitosis. For duplication of...
3.
Schubeis T, Luhrs T, Ritter C
Chembiochem
. 2014 Nov;
16(1):51-4.
PMID: 25394265
We present an efficient method for the reduction of spectral complexity in the solid-state NMR spectra of insoluble protein assemblies, without loss of signal intensity. The approach is based on...
4.
Hellert J, Krausze J, Schulz T, Luhrs T
Acta Crystallogr F Struct Biol Commun
. 2014 Nov;
70(Pt 11):1570-4.
PMID: 25372834
The latency-associated nuclear antigen (LANA) is the latent origin-binding protein and chromatin anchor of the Kaposi's sarcoma herpesvirus (KSHV/HHV-8) genome. Its C-terminal domain (CTD) binds sequence-specifically to the viral origin...
5.
He L, Luhrs T, Ritter C
Biomol NMR Assign
. 2014 Oct;
9(2):223-7.
PMID: 25301530
The mitochondrial antiviral signalling protein (MAVS) is a central signal transduction hub in the innate immune response against viral infections. Viral RNA present in the cytoplasm is detected by retinoic...
6.
Hellert J, Weidner-Glunde M, Krausze J, Richter U, Adler H, Fedorov R, et al.
PLoS Pathog
. 2013 Oct;
9(10):e1003640.
PMID: 24146614
Kaposi sarcoma-associated herpesvirus (KSHV) establishes a lifelong latent infection and causes several malignancies in humans. Murine herpesvirus 68 (MHV-68) is a related γ2-herpesvirus frequently used as a model to study...
7.
Wiesand U, Sorg I, Amstutz M, Wagner S, van den Heuvel J, Luhrs T, et al.
J Mol Biol
. 2008 Nov;
385(3):854-66.
PMID: 18976663
The inner-membrane protein YscU has an important role during the assembly of the Yersinia enterocolitica type III secretion injectisome. Its cytoplasmic domain (YscU(C)) recognizes translocators as individual substrates in the...
8.
Vilar M, Chou H, Luhrs T, Maji S, Riek-Loher D, Verel R, et al.
Proc Natl Acad Sci U S A
. 2008 Jun;
105(25):8637-42.
PMID: 18550842
The aggregation of proteins into amyloid fibrils is associated with several neurodegenerative diseases. In Parkinson's disease it is believed that the aggregation of alpha-synuclein (alpha-syn) from monomers by intermediates into...
9.
Nitschke C, Flechsig E, van den Brandt J, Lindner N, Luhrs T, Dittmer U, et al.
Vet Microbiol
. 2007 May;
123(4):367-76.
PMID: 17499458
Vaccination against prion diseases constitutes a promising approach for the treatment and prevention of the disease. Passive immunisation with antibodies binding to the cellular prion protein (PrP(C)) can protect against...
10.
Nishina K, Deleault N, Mahal S, Baskakov I, Luhrs T, Riek R, et al.
Biochemistry
. 2006 Nov;
45(47):14129-39.
PMID: 17115708
A central event in the formation of infectious prions is the conformational change of a host-encoded glycoprotein, PrPC, into a pathogenic isoform, PrPSc. However, the molecular requirements for efficient PrP...